| Title: | Haplotype estimation for biobank-scale data sets |
| Journal: | Nature Genetics |
| Published: | 6 Jun 2016 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/27270105/ |
| DOI: | https://doi.org/10.1038/ng.3583 |
| URL: | https://europepmc.org/articles/pmc4926957?pdf=render |
Publication 7550
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Abstract
Jonathan Marchini and colleagues develop a new method for haplotype phasing, SHAPEIT3, capable of handling large data sets from biobanks containing >100,000 genotyped samples. They find that their method is fast and accurate, with a low switch error rate, and can be scaled to data sets from increasingly larger cohorts.9 Authors
- Jared O'Connell
- Kevin Sharp
- Nick Shrine
- Louise Wain
- Ian Hall
- Martin Tobin
- Jean-Francois Zagury
- Olivier Delaneau
- Jonathan Marchini
Enabling scientific discoveries that improve human health