| Title: | Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits |
| Journal: | Nature Genetics |
| Published: | 12 Jun 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28604731/ |
| DOI: | https://doi.org/10.1038/ng.3888 |
| URL: | https://research.vu.nl/files/299850892/ng.3888_Genome-wide_association_analysis_of_insomnia_complaints_identifies_risk_genes_and_genetic_overlap_with_psychiatric_and_metabolic_traits.pdf |
| Citations: | 248 (47 in last 2 years) as of 8 Aug 2024 |
Publication 7538
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Abstract
Danielle Posthuma and colleagues report a genome-wide association analysis for insomnia complaints in 113,006 individuals from the UK Biobank that identifies associations with variants near seven genes. They find evidence for sex-specific genetic architectures underlying genetic risk for insomnia and genetic correlations between insomnia complaints and psychiatric and metabolic traits.</p>
24 Keywords
- Adult
- Alleles
- Chromosome Mapping
- Educational Status
- Female
- Gene Expression
- Gene Frequency
- Gene Regulatory Networks
- Genetic Loci
- Genetic Predisposition to Disease
- Genome, Human
- Genome-Wide Association Study
- Homeodomain Proteins
- Humans
- Male
- Myeloid Ecotropic Viral Integration Site 1 Protein
- Neoplasm Proteins
- Polymorphism, Single Nucleotide
- Protein Interaction Mapping
- Quality of Life
- Restless Legs Syndrome
- Sex Factors
- Sleep Initiation and Maintenance Disorders
- Type D Personality
22 Authors
- Anke R Hammerschlag
- Sven Stringer
- Christiaan A de Leeuw
- Suzanne Sniekers
- Erdogan Taskesen
- Kyoko Watanabe
- Tessa F Blanken
- Kim Dekker
- Bart H W te Lindert
- Rick Wassing
- Ingileif Jonsdottir
- Gudmar Thorleifsson
- Hreinn Stefansson
- Thorarinn Gislason
- Klaus Berger
- Barbara Schormair
- Juergen Wellmann
- Juliane Winkelmann
- Kari Stefansson
- Konrad Oexle
- Eus J W Van Someren
- Danielle Posthuma
1 Application
| Application ID | Title |
|---|---|
| 16406 | Causes of individual differences in cognitive and mental health |
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