| Title: | Evidence of directional and stabilizing selection in contemporary humans |
| Journal: | Proceedings of the National Academy of Sciences of the United States of America |
| Published: | 18 Dec 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29255044/ |
| DOI: | https://doi.org/10.1073/pnas.1707227114 |
| URL: | https://europepmc.org/articles/pmc5776788?pdf=render |
| Citations: | 113 (32 in last 2 years) as of 8 Aug 2024 |
Publication 7440
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Abstract
Modern molecular genetic datasets, primarily collected to study the biology of human health and disease, can be used to directly measure the action of natural selection and reveal important features of contemporary human evolution. Here we leverage the UK Biobank data to test for the presence of linear and nonlinear natural selection in a contemporary population of the United Kingdom. We obtain phenotypic and genetic evidence consistent with the action of linear/directional selection. Phenotypic evidence suggests that stabilizing selection, which acts to reduce variance in the population without necessarily modifying the population mean, is widespread and relatively weak in comparison with estimates from other species.</p>
9 Keywords
- Biological Evolution
- Female
- Humans
- Male
- Middle Aged
- Models, Genetic
- Phenotype
- Selection, Genetic
- United Kingdom
5 Authors
- Jaleal S. Sanjak
- Julia Sidorenko
- Matthew R. Robinson
- Kevin R. Thornton
- Peter M. Visscher
1 Application
| Application ID | Title |
|---|---|
| 12505 | Dissecting the genetic basis of relationships between early-life and later-life events |
Enabling scientific discoveries that improve human health