| Title: | Physical activity, dietary protein and insulin-like growth factor 1: Cross-sectional analysis utilising UK Biobank |
| Journal: | Growth Hormone & IGF Research |
| Published: | 24 Sep 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33002777/ |
| DOI: | https://doi.org/10.1016/j.ghir.2020.101353 |
Publication 5548
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Abstract
BACKGROUND: Insulin-like growth factor-I (IGF-1) is an anabolic hormone that stimulates cell growth and division. The effects of IGF-1 may be beneficial (muscle growth/repair) or detrimental (increased risk of several types of cancer and mortality) for health. Dietary protein and physical activity are thought to be factors that modulate IGF-1.</p>
OBJECTIVE: This study analysed the relationships dietary protein vs IGF-1 and physical activity vs IGF-1 independently with a large sample size, and determined if/how physical activity affected the association between dietary protein and IGF-1 in healthy adults.</p>
METHODS: Regression models were used to assess the association between dietary protein and/or physical activity on serum IGF-1 in a cross-sectional sample of 60,677 healthy adults that were enrolled in the UK Biobank project.</p>
RESULTS: Dietary protein was positively associated with IGF-1 (0.030 nmol/L;95%CI 0.027-0.033;p < 0.001). Individuals undertaking 10-50 excess MET h/week of physical activity had 0.129 nmol/L greater IGF-1 than participants completing less than 10 excess MET h/week (95%CI 0.028-0.230). The "high" category of physical activity (>50 excess MET h/week) was not correlated with IGF-1 (-0.055 nmol/L;95%CI -0.185-0.076). When dietary protein and physical activity were included in the same model, physical activity did not change the relationship between dietary protein and IGF-1, nor visa-versa.</p>
CONCLUSIONS: The positive association between dietary protein and IGF-1 was not influenced by physical activity. The former association was stronger than the latter. Thus, when seeking to adjust IGF-1 for possible health concerns, regulating dietary protein may be more pertinent than physical activity as a primary intervention.</p>
15 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Cross-Sectional Studies
- Dietary Proteins
- Exercise
- Female
- Follow-Up Studies
- Humans
- Insulin-Like Growth Factor I
- Male
- Middle Aged
- Prospective Studies
- Surveys and Questionnaires
- United Kingdom
5 Authors
- C.N. Gulick
- M.C. Peddie
- C. Cameron
- K. Bradbury
- N.J. Rehrer
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