| Title: | Obesity as a risk factor for COVID-19 mortality in women and men in the UK biobank: Comparisons with influenza/pneumonia and coronary heart disease |
| Journal: | Diabetes Obesity and Metabolism |
| Published: | 11 Oct 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32969132/ |
| DOI: | https://doi.org/10.1111/dom.14199 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.14199 |
| Citations: | 75 (19 in last 2 years) as of 8 Aug 2024 |
Publication 5488
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Abstract
Obesity is associated with severe COVID-19 outcomes, yet, it is unclear whether the risk of COVID-19 mortality associated with obesity is similar between the sexes. We used data from the UK Biobank to assess the risk of COVID-19 mortality associated with various anthropometric measures in women and men. To put these results in context, we also compared these estimates with those for mortality from influenza/pneumonia and coronary heart disease (CHD). The analyses included 502 493 individuals (54% women), of whom 410 (36% women) died from COVID-19, 549 (36% women) died from influenza/pneumonia and 3355 (19% women) died from CHD. A higher body mass index (BMI), waist circumference, waist-to-hip ratio and waist-to-height ratio were each associated with a greater risk of death from COVID-19, influenza/pneumonia and CHD in both sexes, with the exception of the association between higher BMI and the risk of influenza/pneumonia death in men. A higher BMI was associated with a stronger risk of COVID-19 mortality in women than men; the women-to-men ratio of hazard ratios was 1.20 (95% confidence interval 1.00; 1.43). This study demonstrates the role of obesity in COVID-19 mortality and shows that the relative effects of a higher BMI on COVID-19 mortality may be stronger in women than men.</p>
17 Keywords
- Adult
- Aged
- Body Mass Index
- COVID-19
- Cohort Studies
- Coronary Disease
- Databases, Factual
- Female
- Humans
- Influenza, Human
- Male
- Middle Aged
- Obesity
- Pandemics
- Risk Factors
- SARS-CoV-2
- United Kingdom
3 Authors
- Sanne A. E. Peters
- Stephen MacMahon
- Mark Woodward
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