| Title: | Hypertension is associated with reduced hippocampal connectivity and impaired memory |
| Journal: | EBioMedicine |
| Published: | 22 Oct 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33132184/ |
| DOI: | https://doi.org/10.1016/j.ebiom.2020.103082 |
| URL: | http://www.thelancet.com/article/S2352396420304588/pdf |
Publication 5158
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Abstract
BACKGROUND: The objective was a large-scale analysis of the relation between hypertension, memory problems, and brain function.</p>
METHODS: The study design was to measure the association between a history of hypertension, and the functional connectivity between 94 brain regions, and prospective and numeric memory, in 19,507 participants from the UK Biobank, with cross-validation in 1,002 participants in the Human Connectome Project, and 13,441 individuals in the second release of the UK Biobank. A history of hypertension was measured by whether individuals were admitted to hospital for the treatment of hypertension, with the control group admissions for other reasons.</p>
FINDINGS: A history of hypertension was associated with reduced functional connectivity of the hippocampus, and with reduced prospective memory score (FDR correction p<0.01). The reduced functional connectivity mediated the association between the hypertension history and the prospective memory score. A graded linear relation between both the hippocampal functional connectivity and memory impairment, was found across a wide range of blood pressure (r=-0.04). In 502,537 participants from the UK Biobank, a history of hypertension was associated with impaired prospective memory (p = 9.1 × 10-41, Cohen's d=-0.08) and numeric memory (p = 4.7 × 10-24, Cohen's d=-0.10). The association between hypertension, functional connectivity, and impaired memory was cross-validated with 1,002 participants from the Human Connectome Project; and for functional connectivity in 13,441 individuals in the second release of the UK Biobank imaging dataset.</p>
INTERPRETATION: The reduced functional connectivity of the hippocampus, and the memory impairments, both related to hypertension across a wide range of blood pressure, are important for clinical practice.</p>
18 Keywords
- Aged
- Brain
- Brain Mapping
- Cognition
- Connectome
- Female
- Hippocampus
- Humans
- Hypertension
- Image Processing, Computer-Assisted
- Male
- Memory
- Middle Aged
- Neural Pathways
- Phenotype
- Public Health Surveillance
- Reproducibility of Results
- United Kingdom
4 Authors
- Ruiqing Feng
- Edmund T Rolls
- Wei Cheng
- Jianfeng Feng
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