| Title: | Genetic predisposition to smoking in relation to 14 cardiovascular diseases |
| Journal: | European Heart Journal |
| Published: | 16 Apr 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32300774/ |
| DOI: | https://doi.org/10.1093/eurheartj/ehaa193 |
| URL: | ~Ehttps://watermark.silverchair.com/ehaa193.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAArMwggKvBgkqhkiG9w0BBwagggKgMIICnAIBADCCApUGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMf54eB1oWCeNNu0baAgEQgIICZuYgWswvXWdcJUPsDad_uNgZ0FGbi9UmyZa-pLmPKH9cpxFNWRELQ1-V7nAIGPD7bXFvQ89_EYdQjC7B_2Hfx3cCYIm5r5HL08lPz5jz8cCOd5o80J-u2rfy20eJevnRv28L8Ukngte1CSTwqnDJMCV8RWszIsnzlp0nhrWGE__TZw0Gzxsh0F5Zb-zUgkO-IYA6pTEVMmpTf7fgKIYIbSFvgLZ4ufx10XHLTHOs6Aivktn2RWGIviMLu-EPmBX4788bsHQg1DflksP2hqynvNm1IgtvX5AzZuYJjNVXPt1Sl31JY2cm2pqHrBXNyDYu2ANQCqDktP84aI2yFr4YxQaBOMUcWEA6Hshbh_upWWswTCIQ-nMQ_oXR_xTtvJw-exqU9JpdwwWrJVxhjo9ttdjIE5-iuaxWfY8b4YeXEO0DokHJJYBSibOcjWFyh1Tk45ku-czpHyFgKl5QyMmJIVc25_-4GPVuZ5Hk23vcwtG77i2Zwp08K5EzsbRT4KdUHlpC6Ret4lX1HUhDWZWrKtZqyC5SVwsMhUAI5iWFHWfC6ACxt4tXXDcuNtYK6mwyftyyi1IFRluigVH3npPiXTcscouyX_1ZzCDrzTGWhpR8O_T8SzERzola2Pfd0lEYBLBDCCKSFZnsDyC9vafrLRW4tQh2IUbuxgMzx3oVR25NfwnZ-cyuqTfxcVCM3EZ6Hdww7rE2FfflGaYMDHIR_mY8IKTg2jhMH9Af2HuVmU7KPSmv5IiyxTFa6b1YfBUy-hTj03UWTauX3MXWmqYOu1hrB1XsBcCP5vkB9I8CmwPqJLKoiXx2~ |
| Citations: | 96 (40 in last 2 years) as of 8 Aug 2024 |
Publication 4932
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
AIMS: The aim of this study was to use Mendelian randomization (MR) to determine the causality of the association between smoking and 14 different cardiovascular diseases (CVDs).</p>
METHODS AND RESULTS: Our primary genetic instrument comprised 361 single-nucleotide polymorphisms (SNPs) associated with smoking initiation (ever smoked regularly) at genome-wide significance. Data on the associations between the SNPs and 14 CVDs were obtained from the UK Biobank study (N = 367 643 individuals), CARDIoGRAMplusC4D consortium (N = 184 305 individuals), Atrial Fibrillation Consortium (2017 dataset; N = 154 432 individuals), and Million Veteran Program (MVP; N = 190 266 individuals). The main analyses were conducted using the random-effects inverse-variance weighted method and complemented with multivariable MR analyses and the weighted median and MR-Egger approaches. Genetic predisposition to smoking initiation was most strongly and consistently associated with higher odds of coronary artery disease, heart failure, abdominal aortic aneurysm, ischaemic stroke, transient ischaemic attack, peripheral arterial disease, and arterial hypertension. Genetic predisposition to smoking initiation was additionally associated with higher odds of deep vein thrombosis and pulmonary embolism in the UK Biobank but not with venous thromboembolism in the MVP. There was limited evidence of causal associations of smoking initiation with atrial fibrillation, aortic valve stenosis, thoracic aortic aneurysm, and intracerebral and subarachnoid haemorrhage.</p>
CONCLUSION: This MR study supports a causal association between smoking and a broad range of CVDs, in particular, coronary artery disease, heart failure, abdominal aortic aneurysm, ischaemic stroke, transient ischaemic attack, peripheral arterial disease, and arterial hypertension.</p>
10 Keywords
- Brain Ischemia
- Cardiovascular Diseases
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide
- Risk Factors
- Smoking
- Stroke
8 Authors
- Susanna C Larsson
- Amy M Mason
- Magnus Bäck
- Derek Klarin
- Scott M Damrauer
- Million Veteran Program
- Karl Michaëlsson
- Stephen Burgess
Enabling scientific discoveries that improve human health