: Publication 4815

Publication 4815

Title:	Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study
Journal:	PLOS Medicine
Published:	31 Jan 2019
Pubmed:	https://pubmed.ncbi.nlm.nih.gov/30703100/
DOI:	https://doi.org/10.1371/journal.pmed.1002739
URL:	https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1002739&type=printable

Abstract

BACKGROUND: Psoriasis is a common inflammatory skin disease that has been reported to be associated with obesity. We aimed to investigate a possible causal relationship between body mass index (BMI) and psoriasis.</p>

METHODS AND FINDINGS: Following a review of published epidemiological evidence of the association between obesity and psoriasis, mendelian randomization (MR) was used to test for a causal relationship with BMI. We used a genetic instrument comprising 97 single-nucleotide polymorphisms (SNPs) associated with BMI as a proxy for BMI (expected to be much less confounded than measured BMI). One-sample MR was conducted using individual-level data (396,495 individuals) from the UK Biobank and the Nord-Trøndelag Health Study (HUNT), Norway. Two-sample MR was performed with summary-level data (356,926 individuals) from published BMI and psoriasis genome-wide association studies (GWASs). The one-sample and two-sample MR estimates were meta-analysed using a fixed-effect model. To test for a potential reverse causal effect, MR analysis with genetic instruments comprising variants from recent genome-wide analyses for psoriasis were used to test whether genetic risk for this skin disease has a causal effect on BMI. Published observational data showed an association of higher BMI with psoriasis. A mean difference in BMI of 1.26 kg/m2 (95% CI 1.02-1.51) between psoriasis cases and controls was observed in adults, while a 1.55 kg/m2 mean difference (95% CI 1.13-1.98) was observed in children. The observational association was confirmed in UK Biobank and HUNT data sets. Overall, a 1 kg/m2 increase in BMI was associated with 4% higher odds of psoriasis (meta-analysis odds ratio [OR] = 1.04; 95% CI 1.03-1.04; P = 1.73 × 10(-60)). MR analyses provided evidence that higher BMI causally increases the odds of psoriasis (by 9% per 1 unit increase in BMI; OR = 1.09 (1.06-1.12) per 1 kg/m2; P = 4.67 × 10(-9)). In contrast, MR estimates gave little support to a possible causal effect of psoriasis genetic risk on BMI (0.004 kg/m2 change in BMI per doubling odds of psoriasis (-0.003 to 0.011). Limitations of our study include possible misreporting of psoriasis by patients, as well as potential misdiagnosis by clinicians. In addition, there is also limited ethnic variation in the cohorts studied.</p>

CONCLUSIONS: Our study, using genetic variants as instrumental variables for BMI, provides evidence that higher BMI leads to a higher risk of psoriasis. This supports the prioritization of therapies and lifestyle interventions aimed at controlling weight for the prevention or treatment of this common skin disease. Mechanistic studies are required to improve understanding of this relationship.</p>

28 Authors

Ashley Budu-Aggrey

Ben Brumpton

Jess Tyrrell

Sarah Watkins

Ellen H. Modalsli

Carlos Celis-Morales

Lyn D. Ferguson

Gunnhild Åberge Vie

Tom Palmer

Lars G. Fritsche

Mari Løset

Jonas Bille Nielsen

Wei Zhou

Lam C. Tsoi

Andrew R. Wood

Samuel E. Jones

Robin Beaumont

Marit Saunes

Pål Richard Romundstad

Stefan Siebert

Iain B. McInnes

James T. Elder

George Davey Smith

Timothy M. Frayling

Bjørn Olav Åsvold

Sara J. Brown

Naveed Sattar

Lavinia Paternoster

Abstract

15 Keywords

28 Authors