| Title: | Circulating Insulin-Like Growth Factor-1 and Risk of Total and 19 Site-Specific Cancers: Cohort Study Analyses from the UK Biobank |
| Journal: | Cancer Epidemiology Biomarkers & Prevention |
| Published: | 1 Nov 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32856611/ |
| DOI: | https://doi.org/10.1158/1055-9965.epi-20-0743 |
| URL: | https://cebp.aacrjournals.org/content/cebp/29/11/2332.full.pdf |
| Citations: | 28 (11 in last 2 years) as of 8 Aug 2024 |
Publication 4493
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Abstract
BACKGROUND: Insulin-like growth factor-1 (IGF-1) has been implicated in several malignancies, but few studies have examined multiple cancers simultaneously. We sought to conduct systematic assessments of the association between IGF-1 and cancer risk.</p>
METHODS: We conducted a prospective analysis between IGF-1 and incident total and 19 site-specific cancers among 412,645 individuals enrolled in the UK Biobank with follow-up to 2016. IGF-1 was measured using blood samples provided at the baseline examination. HR and 95% confidence interval (CI) were calculated with multivariable-adjusted Cox models with IGF-1 modeled both in sex-specific quintiles and continuously.</p>
RESULTS: Participants were followed for a median of 7.2 years. We observed positive associations between circulating IGF-1 and overall cancer risk for both men (HR = 1.03 per 5-nmol/L increment in IGF-1; 95% CI, 1.01-1.06) and women (HR = 1.03; 95% CI, 1.01-1.06). For specific sites, we observed positive associations for breast (HR = 1.10; 95% CI, 1.07-1.14), prostate (1.09; 95% CI, 1.05-1.12), colorectum (1.07; 95% CI, 1.02-1.11), melanoma (1.08; 95% CI, 1.01-1.15), kidney (1.10; 95% CI, 1.00-1.20), and thyroid (1.22; 95% CI, 1.05-1.42) and inverse associations for lung (0.91; 95% CI, 0.86-0.96), ovaries (0.86; 95% CI, 0.77-0.95), head and neck (0.90; 95% CI, 0.82-0.99), and liver (0.32; 95% CI, 0.26-0.38). The inverse association between IGF-1 and lung cancer was observed only in ever-smokers (HRever-smoker = 0.88 vs. HRnever-smoker = 1.14; Pinteraction = 0.0005). Analyses comparing extreme quintiles were consistent.</p>
CONCLUSIONS: IGF-1 is modestly associated with increased risk of total cancer in both men and women but demonstrated divergent associations for site-specific cancers.</p>
IMPACT: Our study suggests that IGF-1 could serve as a target for cancer prevention or treatment.</p>
13 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Cohort Studies
- Female
- Humans
- Insulin-Like Growth Factor I
- Male
- Middle Aged
- Neoplasms
- Prospective Studies
- Risk Factors
- United Kingdom
2 Authors
- Frank Qian
- Dezheng Huo
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