| Title: | Cardiometabolic disease and features of depression and bipolar disorder: Population-based, cross-sectional study |
| Journal: | The British Journal of Psychiatry |
| Published: | 1 Apr 2016 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/26795427/ |
| DOI: | https://doi.org/10.1192/bjp.bp.114.157784 |
| URL: | ~Ehttps://www.cambridge.org/core/services/aop-cambridge-core/content/view/03942476FE4224EC59220F1DD5A4578C/S0007125000240877a.pdf/div-class-title-cardiometabolic-disease-and-features-of-depression-and-bipolar-disorder-population-based-cross-sectional-study-div.pdf~ |
Publication 4413
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Abstract
BACKGROUND: The relative contribution of demographic, lifestyle and medication factors to the association between affective disorders and cardiometabolic diseases is poorly understood.AIMS: To assess the relationship between cardiometabolic disease and features of depresion and bipolar disorder within a large population sample.
METHOD: Cross-sectional study of 145 991 UK Biobank participants: multivariate analyses of associations between features of depression or bipolar disorder and five cardiometabolic outcomes, adjusting for confounding factors.
RESULTS: There were significant associations between mood disorder features and 'any cardiovascular disease' (depression odds ratio (OR) = 1.15, 95% CI 1.12-1.19; bipolar OR = 1.28, 95% CI 1.14-1.43) and with hypertension (depression OR = 1.15, 95% CI 1.13-1.18; bipolar OR = 1.26, 95% CI 1.12-1.42). Individuals with features of mood disorder taking psychotropic medication were significantly more likely than controls not on psychotropics to report myocardial infarction (depression OR = 1.47, 95% CI 1.24-1.73; bipolar OR = 2.23, 95% CI 1.53-3.57) and stroke (depression OR = 2.46, 95% CI 2.10-2.80; bipolar OR = 2.31, 95% CI 1.39-3.85).
CONCLUSIONS: Associations between features of depression or bipolar disorder and cardiovascular disease outcomes were statistically independent of demographic, lifestyle and medication confounders. Psychotropic medication may also be a risk factor for cardiometabolic disease in individuals without a clear history of mood disorder.
15 Authors
- Daniel J. Martin
- Zia Ul-Haq
- Barbara I. Nicholl
- Breda Cullen
- Jonathan Evans
- Jason M. R. Gill
- Beverly Roberts
- John Gallacher
- Daniel Mackay
- Andrew McIntosh
- Matthew Hotopf
- Nick Craddock
- Ian J. Deary
- Jill P. Pell
- Daniel J. Smith
Enabling scientific discoveries that improve human health