| Title: | Association between childhood trauma and risk for obesity: a putative neurocognitive developmental pathway |
| Journal: | BMC Medicine |
| Published: | 15 Oct 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33054810/ |
| DOI: | https://doi.org/10.1186/s12916-020-01743-2 |
| URL: | https://bmcmedicine.biomedcentral.com/track/pdf/10.1186/s12916-020-01743-2 |
| Citations: | 10 (7 in last 2 years) as of 8 Aug 2024 |
Publication 4132
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Abstract
BackgroundChildhood trauma increases the risk for adult obesity through multiple complex pathways, and the neural substrates are yet to be determined.MethodsParticipants from three population-based neuroimaging cohorts, including the IMAGEN cohort, the UK Biobank (UKB), and the Human Connectome Project (HCP), were recruited. Voxel-based morphometry analysis of both childhood trauma and body mass index (BMI) was performed in the longitudinal IMAGEN cohort; validation of the findings was performed in the UKB. White-matter connectivity analysis was conducted to study the structural connectivity between the identified brain region and subdivisions of the hypothalamus in the HCP.ResultsIn IMAGEN, a smaller frontopolar cortex (FPC) was associated with both childhood abuse (CA) (β = − .568, 95%CI − .942 to − .194; p = .003) and higher BMI (β = − .086, 95%CI − .128 to − .043; p < .001) in male participants, and these findings were validated in UKB. Across seven data collection sites, a stronger negative CA-FPC association was correlated with a higher positive CA-BMI association (β = − 1.033, 95%CI − 1.762 to − .305; p = .015). Using 7-T diffusion tensor imaging data (n = 156), we found that FPC was the third most connected cortical area with the hypothalamus, especially the lateral hypothalamus. A smaller FPC at age 14 contributed to higher BMI at age 19 in those male participants with a history of CA, and the CA-FPC interaction enabled a model at age 14 to account for some future weight gain during a 5-year follow-up (variance explained 5.8%).ConclusionsThe findings highlight that a malfunctioning, top-down cognitive or behavioral control system, independent of genetic predisposition, putatively contributes to excessive weight gain in a particularly vulnerable population, and may inform treatment approaches.</p>
35 Authors
- Qiang Luo
- Lingli Zhang
- Chu-Chung Huang
- Yan Zheng
- Jonathan W. Kanen
- Qi Zhao
- Ye Yao
- Erin B. Quinlan
- Tianye Jia
- Tobias Banaschewski
- Arun L. W. Bokde
- Uli Bromberg
- Christian Büchel
- Herta Flor
- Vincent Frouin
- Hugh Garavan
- Penny Gowland
- Andreas Heinz
- Bernd Ittermann
- Jean-Luc Martinot
- Marie-Laure Paillère Martinot
- Frauke Nees
- Dimitri Papadopoulos Orfanos
- Luise Poustka
- Sarah Hohmann
- Juliane H. Fröhner
- Michael N. Smolka
- Henrik Walter
- Robert Whelan
- Barbara J. Sahakian
- Gunter Schumann
- Fei Li
- Jianfeng Feng
- Sylvane Desrivières
- Trevor W. Robbins
Enabling scientific discoveries that improve human health