| Title: | A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine |
| Journal: | Nature Communications |
| Published: | 6 Jul 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32632093/ |
| DOI: | https://doi.org/10.1038/s41467-020-17002-0 |
| URL: | https://kclpure.kcl.ac.uk/portal/en/publications/05007df8-e491-4447-b116-dd3a08da0325 |
| Citations: | 45 (23 in last 2 years) as of 8 Aug 2024 |
Publication 3891
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Abstract
Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10−06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = −0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10−08), nine of which replicate (P < 0.05) in the UK Biobank. Five shared loci (ITGB5, SMG6, ADRA2B, ANKDD1B, and KIAA0040) are reinforced in gene-level analysis and highlight potential mechanisms involving vascular development, endothelial function and calcium homeostasis. Mendelian randomization reveals stronger instrumental estimates of DBP (OR [95% CI] = 1.20 [1.15-1.25]/10 mmHg; P = 5.57 × 10−25) on migraine than SBP (1.05 [1.03-1.07]/10 mmHg; P = 2.60 × 10−07) and a corresponding opposite effect for PP (0.92 [0.88-0.95]/10 mmHg; P = 3.65 × 10−07). These findings support a critical role of DBP in migraine susceptibility and shared biology underlying BP and migraine.</p>
14 Keywords
- Blood Pressure
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Hypertension
- Integrin beta Chains
- Mendelian Randomization Analysis
- Meta-Analysis as Topic
- Migraine Disorders
- Polymorphism, Single Nucleotide
- Proteins
- Receptors, Adrenergic, alpha-2
- Risk Factors
- Telomerase
6 Authors
- Yanjun Guo
- Pamela M. Rist
- Iyas Daghlas
- Franco Giulianini
- Tobias Kurth
- Daniel I. Chasman
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