| Title: | A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure |
| Journal: | Cell Reports |
| Published: | 10 Apr 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29641994/ |
| DOI: | https://doi.org/10.1016/j.celrep.2018.03.070 |
| URL: | https://curis.ku.dk/ws/files/211865248/1_s2.0_S2211124718304315_main.pdf |
| Citations: | 81 (19 in last 2 years) as of 8 Aug 2024 |
Publication 3860
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Abstract
Fibroblast growth factor 21 (FGF21) is a hormone that has insulin-sensitizing properties. Some trials of FGF21 analogs show weight loss and lipid-lowering effects. Recent studies have shown that a common allele in the FGF21 gene alters the balance of macronutrients consumed, but there was little evidence of an effect on metabolic traits. We studied a common FGF21 allele (A:rs838133) in 451,099 people from the UK Biobank study, aiming to use the human allele to inform potential adverse and beneficial effects of targeting FGF21. We replicated the association between the A allele and higher percentage carbohydrate intake. We then showed that this allele is more strongly associated with higher blood pressure and waist-hip ratio, despite an association with lower total body-fat percentage, than it is with BMI or type 2 diabetes. These human phenotypes of variation in the FGF21 gene will inform research into FGF21's mechanisms and therapeutic potential.</p>
19 Keywords
- Adult
- Aged
- Alcohol Drinking
- Alleles
- Blood Pressure
- Body Fat Distribution
- Body Mass Index
- Body Size
- Databases, Factual
- Diabetes Mellitus, Type 2
- Diet, High-Fat
- Fibroblast Growth Factors
- Genome-Wide Association Study
- Humans
- Middle Aged
- Phenotype
- Polymorphism, Single Nucleotide
- Sugars
- United Kingdom
26 Authors
- Timothy M. Frayling
- Robin N. Beaumont
- Samuel E. Jones
- Hanieh Yaghootkar
- Marcus A. Tuke
- Katherine S. Ruth
- Francesco Casanova
- Ben West
- Jonathan Locke
- Seth Sharp
- Yingjie Ji
- William Thompson
- Jamie Harrison
- Amy S. Etheridge
- Paul J. Gallins
- Dereje Jima
- Fred Wright
- Yihui Zhou
- Federico Innocenti
- Cecilia M. Lindgren
- Niels Grarup
- Anna Murray
- Rachel M. Freathy
- Michael N. Weedon
- Jessica Tyrrell
- Andrew R. Wood
Enabling scientific discoveries that improve human health