| Title: | Adherence to a healthy lifestyle and multiple sclerosis: a case-control study from the UK Biobank |
| Journal: | Nutritional Neuroscience |
| Published: | 9 Dec 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33297884/ |
| DOI: | https://doi.org/10.1080/1028415x.2020.1846357 |
| Citations: | 7 (4 in last 2 years) as of 8 Aug 2024 |
Publication 3823
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Abstract
BACKGROUND: Multiple sclerosis (MS) is a common and disabling condition. The importance of healthy lifestyle for this disease is poorly explored.</p>
OBJECTIVE: To test whether adherence to healthier lifestyle patterns is associated with a lower presence of multiple sclerosis (MS).</p>
METHODS: By using a case-control design, we investigated the combined association of four healthy lifestyle-related factors (no current smoking, healthy diet, exercising regularly, body mass index <30 kg/m2) and the prevalence of MS. A logistic regression analysis, adjusted for potential confounders, was used and data reported as odds ratios (ORs) with their 95% confidence intervals (CIs).</p>
RESULTS: 728 participants with MS were matched with healthy controls (n = 2,912) using a propensity score approach. In a multivariable analysis, compared to those who scored low in the composite lifestyle score (0-1 healthy lifestyle factors), people who adopted all four low risk lifestyle factors showed a 71% lower odds of having MS (OR = 0.29; 95% CI: 0.15-0.56). Moreover, there was a strong linear trend, suggesting that the higher number of healthy lifestyle behaviors was associated with lower odds of having MS.</p>
CONCLUSION: Following a healthy lifestyle is associated with a lower prevalence of MS. This association should be explored further in cohort studies.</p>
8 Keywords
- Biological Specimen Banks
- Case-Control Studies
- Healthy Lifestyle
- Humans
- Life Style
- Multiple Sclerosis
- Risk Factors
- United Kingdom
13 Authors
- Nicola Veronese
- Lin Yang
- Laura Piccio
- Lee Smith
- Joseph Firth
- Wolfgang Marx
- Gianluigi Giannelli
- Maria Gabriella Caruso
- Anna Maria Cisternino
- Maria Notarnicola
- Rossella Donghia
- Mario Barbagallo
- Luigi Fontana
1 Application
| Application ID | Title |
|---|---|
| 41245 | Importance of healthy lifestyle on chronic neurological conditions |
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