| Title: | Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank |
| Journal: | Journal of Internal Medicine |
| Published: | 6 Nov 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31623012/ |
| DOI: | https://doi.org/10.1111/joim.12994 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/joim.12994 |
Publication 3691
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Abstract
OBJECTIVE: To examine the association between the MTNR1B G risk allele, type 2 diabetes (T2D) and chronotype in the UK Biobank.</p>
METHODS: Data from the baseline investigation of the UK Biobank were utilized (n = 337 083 White British; mean age: 56.9 years; 54% women). MTNR1B rs10830963 was directly genotyped [CC (reference group), CG and GG]. Chronotype was divided into four categories: definitely morning (reference group); more morning than evening; more evening than morning; and definitely evening. Logistic regression analyses were performed to estimate odds ratios and 95% confidence intervals (CIs) for T2D, controlling for age, sex and other confounders.</p>
RESULTS: Carriers of the rs10830963 risk allele had a higher risk of T2D [CG vs. CC: OR (95% CI) 1.10 (1.07, 1.15); GG vs. CC: 1.21 (1.14, 1.29)]. Compared with definitely morning chronotype, participants with definitely evening chronotype exhibited the highest risk of T2D [1.25 (1.17, 1.33)]. Despite a nonsignificant interaction between chronotype and the risk allele [0.98 (0.94, 1.01), P = 0.176 for interaction term], we found that definitely evening chronotype (vs. definitely morning) was linked with a higher risk of T2D amongst CC and CG but not GG carriers. Additionally, we saw that the GG genotype (vs. CC) was associated with a higher risk of T2D across all chronotype categories, except for definitely evening.</p>
CONCLUSION: Our findings suggest that the MTNR1B G risk allele and late chronotype increase the risk of T2D. The association between late chronotype and higher risk of T2D appears to vary across MTNR1B rs10830963 genotypes.</p>
13 Keywords
- Alleles
- Biological Specimen Banks
- Circadian Rhythm
- Diabetes Mellitus, Type 2
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Receptor, Melatonin, MT2
- Risk Assessment
- Risk Factors
- United Kingdom
4 Authors
- X. Tan
- D.-M. Ciuculete
- H.B. Schiöth
- C. Benedict
1 Application
| Application ID | Title |
|---|---|
| 43015 | Melatonin, lifestyle, and health: a gene-environmental investigation in the UK Biobank |
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