| Title: | Vitamin D concentrations and COVID-19 infection in UK Biobank |
| Journal: | Diabetes & Metabolic Syndrome Clinical Research & Reviews |
| Published: | 7 May 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32413819/ |
| DOI: | https://doi.org/10.1016/j.dsx.2020.04.050 |
| URL: | https://europepmc.org/articles/pmc7204679 |
| Citations: | 386 (38 in last 2 years) as of 8 Aug 2024 |
Publication 3675
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Abstract
BACKGROUND AND AIMS: COVID-19 and low levels of vitamin D appear to disproportionately affect black and minority ethnic individuals. We aimed to establish whether blood 25-hydroxyvitamin D (25(OH)D) concentration was associated with COVID-19 risk, and whether it explained the higher incidence of COVID-19 in black and South Asian people.</p>
METHODS: UK Biobank recruited 502,624 participants aged 37-73 years between 2006 and 2010. Baseline exposure data, including 25(OH)D concentration and ethnicity, were linked to COVID-19 test results. Univariable and multivariable logistic regression analyses were performed for the association between 25(OH)D and confirmed COVID-19, and the association between ethnicity and both 25(OH)D and COVID-19.</p>
RESULTS: Complete data were available for 348,598 UK Biobank participants. Of these, 449 had confirmed COVID-19 infection. Vitamin D was associated with COVID-19 infection univariably (OR = 0.99; 95% CI 0.99-0.999; p = 0.013), but not after adjustment for confounders (OR = 1.00; 95% CI = 0.998-1.01; p = 0.208). Ethnicity was associated with COVID-19 infection univariably (blacks versus whites OR = 5.32, 95% CI = 3.68-7.70, p-value<0.001; South Asians versus whites OR = 2.65, 95% CI = 1.65-4.25, p-value<0.001). Adjustment for 25(OH)D concentration made little difference to the magnitude of the association.</p>
CONCLUSIONS: Our findings do not support a potential link between vitamin D concentrations and risk of COVID-19 infection, nor that vitamin D concentration may explain ethnic differences in COVID-19 infection.</p>
20 Keywords
- Adult
- Aged
- Asian People
- Betacoronavirus
- Black People
- COVID-19
- Causality
- Coronavirus Infections
- Databases, Factual
- Female
- Health Surveys
- Humans
- Male
- Middle Aged
- Pandemics
- Pneumonia, Viral
- SARS-CoV-2
- United Kingdom
- Vitamin D
- Vitamin D Deficiency
14 Authors
- Claire E Hastie
- Daniel F Mackay
- Frederick Ho
- Carlos A Celis-Morales
- Srinivasa Vittal Katikireddi
- Claire L Niedzwiedz
- Bhautesh D Jani
- Paul Welsh
- Frances S Mair
- Stuart R Gray
- Catherine A O'Donnell
- Jason Mr Gill
- Naveed Sattar
- Jill P Pell
1 Application
| Application ID | Title |
|---|---|
| 7155 | Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
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