| Title: | Alzheimer's Disease Susceptibility Gene Apolipoprotein E (APOE) and Blood Biomarkers in UK Biobank (N = 395,769) |
| Journal: | J Alzheimers Dis |
| Published: | 18 Aug 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32651323/ |
| DOI: | https://doi.org/10.3233/JAD-200338 |
Publication 3403
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Abstract
APOE e4 genotype is a common risk factor for Alzheimer's disease and accelerated cognitive ageing. However we know little about its associations with blood biomarkers like low-density lipoprotein cholesterol, in non-demented people. Here, we showed in n=400k people, that there are associations between risk e4 genotype and protective e2 genotypes in terms of lipid, neuroinflammation and to a lesser extent other circulating blood biomarker levels. These could suggest future biomarkers of interest for dementia, although further study is required.1 Author
- Ferguson AC et al.
1 Application
| Application ID | Title |
|---|---|
| 17689 | Genetic, environmental and lifestyle predictors of brain/cognitive-related outcomes. |
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