| Title: | BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank |
| Journal: | Diabetes & Metabolic Syndrome Clinical Research & Reviews |
| Published: | 30 Jun 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32668401/ |
| DOI: | https://doi.org/10.1016/j.dsx.2020.06.060 |
Publication 3377
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Abstract
AIMS: We examined the link between BMI and risk of a positive test for SARS-CoV-2 and risk of COVID-19-related death among UK Biobank participants.</p>
METHODS: Among 4855 participants tested for SARS-CoV-2 in hospital, 839 were positive and of these 189 died from COVID-19. Poisson models with penalised thin plate splines were run relating exposures of interest to test positivity and case-fatality, adjusting for confounding factors.</p>
RESULTS: BMI was associated strongly with positive test, and risk of death related to COVID-19. The gradient of risk in relation to BMI was steeper in those under 70, compared with those aged 70 years or older for COVID-19 related death (Pinteraction = 0.03). BMI was more strongly related to test positivity (Pinteraction = 0.010) and death (Pinteraction = 0.002) in non-whites (predominantly South Asians and Afro-Caribbeans), compared with whites.</p>
CONCLUSIONS: These data add support for adiposity being more strongly linked to COVID-19-related deaths in younger people and non-white ethnicities. If future studies confirm causality, lifestyle interventions to improve adiposity status may be important to reduce the risk of COVID-19 in all, but perhaps particularly, non-white communities.</p>
16 Keywords
- Age Factors
- Betacoronavirus
- Biological Specimen Banks
- Body Mass Index
- COVID-19
- Coronavirus Infections
- Ethnicity
- Humans
- Pandemics
- Pneumonia, Viral
- Prognosis
- Risk Factors
- SARS-CoV-2
- Sex Factors
- Survival Rate
- United Kingdom
11 Authors
- Naveed Sattar
- Frederick K. Ho
- Jason MR. Gill
- Nazim Ghouri
- Stuart R. Gray
- Carlos A. Celis-Morales
- S. Vittal Katikireddi
- Colin Berry
- Jill P. Pell
- John JV. McMurray
- Paul Welsh
1 Application
| Application ID | Title |
|---|---|
| 7155 | Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
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