| Title: | How robust are cross-population signatures of polygenic adaptation to the choice of GWAS cohort? |
| Journal: | bioRxiv (2020) |
| Published: | 8 Apr 2021 |
| DOI: | https://doi.org/10.1101/2020.07.13.200030 |
Publication 3289
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Abstract
We collated GWAS data from multiple traits measured accross several diverse cohortse cohorts: UK Biobank, FINRISK, Chinese NIPT, Biobank Japan, APCDR and PAGE. We evaluated how robust signals of polygenic adaptation are to the choice of GWAS cohort used to identify associated variants and their effect size estimates. We show that meta analysis creates overdispersion across populations which appears likes signs of polygenetic seleciton.1 Author
- Refoyo-Martinez et al
1 Application
| Application ID | Title |
|---|---|
| 32683 | Combined effect of the genetic and lifestyle determinants of metabolic syndrome on cardiometabolic risk |
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