| Title: | Is smoking heaviness causally associated with alcohol use? A Mendelian randomization study in four European cohorts |
| Journal: | Int J Epidemiol |
| Published: | 1 Aug 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29509885/ |
| DOI: | https://doi.org/10.1093/ije/dyy027 |
Publication 2827
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Abstract
There is strong evidence of a positive association between cigarette and alcohol consumption. We tested whether smoking is likely to increase alcohol consumption using a genetic variant (rs1051730/rs16969968) which increases smoking heaviness in four studies: UK Biobank, ALSPAC, HUNT and the Copenhagen General Population Study. Whilst we saw a strong association between self-reported smoking and alcohol consumption, there was little evidence that the smoking increasing variant was associated with alcohol consumption in smokers. Previously reported associations between smoking and alcohol are unlikely to be causal, and may be the result of confounding and/or reverse causation.18 Keywords
- Adult
- Aged
- Aged, 80 and over
- Alcohol Drinking
- Alleles
- Causality
- Cigarette Smoking
- Databases, Factual
- Europe
- Female
- Humans
- Linear Models
- Longitudinal Studies
- Male
- Mendelian Randomization Analysis
- Middle Aged
- Polymorphism, Single Nucleotide
- Young Adult
1 Author
- Taylor M et al.
1 Application
| Application ID | Title |
|---|---|
| 9142 | Using Mendelian Randomisation to investigate the causal effects of caffeine and smoking on health outcomes. |
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