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Higher intensity, longer duration, higher cumulative dose, earlier age at start smoking, and shorter time since quitting smoking were significantly associated with higher risk of premature (<40 years) and early menopause (40-44 years), as well as earlier menopause at 45 49 years. Duration of smoking was a strong predictor of age at natural menopause. Smokers who had quit smoking for more than 10 years had similar risk as never smokers.