| Title: | Association of Total and Differential Leukocyte Counts With Cardiovascular Disease and Mortality in the UK Biobank |
| Journal: | Arteriosclerosis Thrombosis and Vascular Biology |
| Published: | 26 Apr 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29699973/ |
| DOI: | https://doi.org/10.1161/atvbaha.118.310945 |
| URL: | https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.118.310945 |
Publication 2618
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Abstract
OBJECTIVE: Elevated white blood cell count is associated with a higher risk of cardiovascular disease (CVD). We aimed to investigate whether specific leukocyte subpopulations, which may more closely indicate a specific inflammatory pathway, are specifically associated with CVD.</p>
APPROACH AND RESULTS: Participants (478 259) from UK Biobank with data for white blood cell count were included. Death because of CVD (n=1377) and non-CVD causes (n=8987) occurred during median follow-up time of 7.0 years (interquartile range, 6.3-7.6). In Cox models, deciles of leukocyte counts (lymphocytes, monocytes, neutrophils, eosinophils, and basophils) were examined using the fifth decile as the referent group. Models were stratified by sex and adjusted for a range of classical risk factors. A sensitivity analysis excluded participants with baseline comorbidites and the first 2 years of follow-up. Men (hazard ratio [HR], 1.59; 95% confidence interval, 1.22-2.08) and women (HR, 2.15; 95% confidence interval, 1.38-3.35) in the highest decile of neutrophil count were at higher risk of CVD mortality and nonfatal CVD (men HR, 1.28; 95% confidence interval, 1.16-1.42 and women HR, 1.21; 95% confidence interval, 1.06-1.38). In the sensitivity analysis, the power to investigate CVD mortality was limited, but for both sexes combined, the linear HRs for a 1×109/L cell count increase in white blood cell count and neutrophils, respectively, was 1.05 (1.03-1.07) and 1.07 (1.04-1.11).</p>
CONCLUSIONS: Among circulating leukocyte subpopulations, neutrophil count in men was most consistently associated with fatal and nonfatal CVD. Further studies of interventions that lower circulating neutrophils, such as canakinumab, are required to investigate causality.</p>
19 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Cardiovascular Diseases
- Comorbidity
- Female
- Humans
- Leukocyte Count
- Male
- Middle Aged
- Neutrophils
- Predictive Value of Tests
- Prognosis
- Prospective Studies
- Risk Assessment
- Risk Factors
- Sex Factors
- Time Factors
- United Kingdom
12 Authors
- Claire Welsh
- Paul Welsh
- Patrick B Mark
- Carlos A Celis-Morales
- James Lewsey
- Stuart R Gray
- Donald M Lyall
- Stamatina Iliodromiti
- Jason M R Gill
- Jill Pell
- Pardeep S Jhund
- Naveed Sattar
1 Application
| Application ID | Title |
|---|---|
| 9310 | Associations of blood biomarkers with cardiovascular disease and related cardiometabolic outcomes and risk prediction in the clinical setting |
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