| Title: | Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis |
| Journal: | J Hepatol |
| Published: | 1 Aug 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32247823/ |
| DOI: | https://doi.org/10.1016/j.jhep.2020.03.032 |
Publication 2343
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Abstract
We estimated levels of liver inflammation and scarring based on magnetic resonance imaging of 14,440 UK Biobank participants. We performed a genetic study and identified variations in 6 genes associated with levels of liver inflammation and scarring. Participants with variations in 4 of these genes also had higher levels of markers of liver cell injury in blood samples, further validating their role in liver health. Two identified genes are involved in the transport of metal ions in our body. Further investigation of these variations may lead to better detection, assessment, and/or treatment of liver inflammation and scarring.1 Author
- Parisinos CA et al.
1 Application
| Application ID | Title |
|---|---|
| 9914 | Determining the Outcomes of People with Liver Disease |
Enabling scientific discoveries that improve human health