| Title: | Associations of long-term exposure to source-specific PM2.5, lifestyle, and genetic susceptibility with dementia risk: a prospective cohort study |
| Journal: | European Archives of Psychiatry and Clinical Neuroscience |
| Published: | 9 Oct 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42853264/ |
| DOI: | https://doi.org/10.1007/s00406-026-02391-y |
Publication 21569
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Abstract
ObjectivesThe impact of source-specific PM2.5 on dementia and its subtypes is limited. We aimed to investigate the association between source-specific PM2.5 and the risk of incident dementia and explore whether genetic susceptibility and lifestyle modified these associations.MethodsWe used Cox models with time-varying exposure measurements to evaluate the associations of source-specific PM2.5 with incident dementia. A polygenic risk score and a lifestyle score were constructed to assess whether those factors could modify the effect of source-specific PM2.5 on dementia risk.ResultsDuring a median follow-up of 11.9 years, a total of 5,648 incident all-cause dementia cases were identified. The adjusted hazard ratios for dementia associated with an interquartile range increase in PM2.5 from domestic, transport, other transport, and industry sources were 1.05 (1.01, 1.08), 1.12 (1.04, 1.21), 1.12 (1.06, 1.19), and 1.07 (1.03, 1.11), respectively. For the combined associations, Participants with high levels of source-specific PM2.5 exposure and high genetic susceptibility had a greater risk of incident dementia compared to those with the lowest pollutant exposure and lowest genetic risk (∼236% to 352%). A similar pattern was observed for the joint relationship between source-specific PM2.5 and lifestyle factors.ConclusionsHigher source-specific PM2.5 exposure levels were associated with a higher risk of incident dementia. Our findings indicate that source-specific reduction strategies and targeted preventive approaches for high-risk groups might be associated with a lower risk of incident dementia.</p>
7 Authors
- Rui Tang
- Linxi Tang
- Lei Zheng
- Yudiyang Ma
- Ning Chen
- Xiaoying Zheng
- Yaohua Tian
1 Application
| Application ID | Title |
|---|---|
| 69741 | Environmental exposures, medicine use, genetic susceptibility, and the risk of cardiovascular diseases and psychiatric disorders |
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