| Title: | Whole blood transcriptomics atlas across human diseases |
| Journal: | Nature Communications |
| Published: | 12 Oct 2026 |
| DOI: | https://doi.org/10.1038/s41467-026-78440-w |
| URL: | https://www.nature.com/articles/s41467-026-78440-w_reference.pdf |
Publication 21546
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Abstract
We present a WBT Atlas, comprising 4444 WBT samples across 98 distinct health conditions, enabling systematic exploration of disease-associated transcriptomic signatures. Health condition-specific profiles are characterized across immune, metabolic, and cell-type specific features at the gene, gene module, and pathway levels. By integrating matched plasma proteomics data from 1280 participants across 28 health conditions, we further assess blood RNA-protein relationships and demonstrate their complementary biological roles. By integrating RNA and protein signatures, we develop multi-class classification models that accurately distinguish among a wide range of health conditions, with integrated models consistently outperforming those based on single-omics data alone. The identified RNA and protein signatures are validated across ten independent WBT cohorts and the UK Biobank. Together, the WBT Atlas provides a genome-wide resource that enables translational discovery in precision medicine.</p>
110 Authors
- Mengzhen Li
- Abdulgani Tatar
- Emre Green
- Ebru Simsek
- Cigdem Yuce Kahraman
- Mustafa Ceylan
- Fuat Laloglu
- Naci Ceviz
- Arzu Tatar
- Esra Laloglu
- Gungor Akcay
- Kenan Cadirci
- Omer Erkan Yapca
- Hilal Kiziltunc Ozmen
- Turgut Yapanoglu
- Ozlem Kudas
- Fatma Simsek
- Emsal Pinar Topdagi Yılmaz
- Gamze Nur Cimilli Senocak
- Hakan Doneray
- Ayse Ozden
- Atilla Cayir
- Pinar Tosun Tasar
- Mustafa Kara
- Yunus Emre Aktaş
- Mursel Karadavut
- Busra Akpinar
- Eyup Serhat Calik
- Bilgehan Erkut
- Mufide Akcay
- Erdem Karadeniz
- Murat Kartal
- Esra Disci
- Mehmet Ilhan Yildirgan
- Sabri Selcuk Atamanalp
- Rifat Peksoz
- Yavuz Albayrak
- Atilla Eroglu
- Yener Aydın
- Sultan Tuna Akgol Gur
- Mevlana Gul
- Erdal Tekin
- Ali Bilal Ulas
- Eyup Senocak
- Ahmet Emre Paksoy
- Ayse Sena Donmez
- Mehmet Cenk Turgut
- Ozgur Ozmen
- Fatih Alper
- Hasan Abbas Guliyev
- Bulent Albayrak
- Emine Cinici
- Ibrahim Kocer
- Esat Fahri Aydın
- Nazim Dogan
- Yahya Gul
- Ugur Kaya
- Yunus Emre Topdagi
- Yakup Kumtepe
- Aysenur Dostbil
- Husnu Kursat
- Nuray Bilge
- Ozkan Cinici
- Esra Disci
- Derya Cevizli
- Muhammed Akif Guler
- Halil Ozcan
- Tugba Koca Lacin
- Serap Sari
- Bugra Kerget
- Omer Araz
- Fatma Tortum
- Necip Altundas
- Nurhak Aksungur
- Salih Kara
- Gurkan Ozturk
- Serap Kilic Kaya
- Merve Ulku
- Fatma Kesmez Can
- Handan Alay
- Ayse Albayrak
- Kemalettin Ozden
- Ertugrul Karatas
- Mirze Muhammet Ozen
- Ali Gur
- Taner Arabaci
- Sinan Yilar
- Serdar Saritas
- Zulal Ozkurt
- Hacer Akgul Ceyhun
- Can Sevinc
- Mehmet Akif Sirin
- Gulden Sincan
- Momen Kanjee
- Busra Saruhan
- Sumeyye Ozturk Eren
- Bahadir Utlu
- Muhammed Hakan Tas
- Esra Tanriverdi
- María Bueno Álvez
- Fredrik Edfors
- Xiangtai Kong
- Xiya Song
- Ozlem Altay
- Bayram Yuksel
- Mathias Uhlen
- Saeed Shoaie
- Cheng Zhang
- Hasan Turkez
- Adil Mardinoglu
1 Application
| Application ID | Title |
|---|---|
| 150710 | Integrative multi-omics analysis of the molecular basis for the health development of newborns |
Enabling scientific discoveries that improve human health