| Title: | Triglyceride-Glucose-Related Indexes as Risk Factors for Vision-Threatening Ocular Diseases: A Prospective UK Biobank Study |
| Journal: | Investigative Ophthalmology & Visual Science |
| Published: | 19 Aug 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42615799/ |
| DOI: | https://doi.org/10.1167/iovs.67.10.48 |
| URL: | http://dx.doi.org/10.1167/iovs.67.10.48 |
Publication 20959
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Background: To evaluate the associations of the triglyceride-glucose (TyG) index and related obesity-combined indexes with the incidence of major vision-threatening ocular diseases.</p>
Methods: This prospective population-based cohort study included 400,237 participants from the UK Biobank. The TyG index and derived indexes (combined with waist circumference, waist-to-height ratio, and body mass index) were calculated using baseline laboratory and anthropometric data. The outcomes were incident cases of cataract, POAG, AMD, and diabetic retinopathy (DR), ascertained using self-reported data, hospital inpatient records, and primary care records. Cox proportional hazards models were used, with restricted cubic splines fitted to characterize dose-response relationships. Secondary analyses assessed the associations with retinal thicknesses and vascular features.</p>
Results: Over a median follow-up of 13.0 years, 46,151 cataract, 6317 POAG, 8276 AMD, and 5220 DR incident cases were identified. Distinct nonlinear associations were observed: the TyG index exhibited a reverse L-shaped relationship with cataract and DR, a J-shaped association with AMD, and a U-shaped relationship with POAG (all P total < 0.01, all P nonlinear < 0.05), suggesting an estimated optimal range from 8.6 to 9.1. Furthermore, elevated TyG-obesity indexes exhibited monotonic positive associations with the risk of cataract, AMD, and DR (all P total < 0.001), whereas moderate elevation was associated with a reduced risk of POAG (all P total < 0.01, all P nonlinear < 0.05). Elevated TyG-obesity indexes were also associated with retinal thinning and vascular abnormalities, providing supportive discrimination and risk-stratification information for incident DR.</p>
Conclusions: The TyG index and related obesity-combined indexes show disease-specific associations with major sight-threatening conditions, accompanied by retinal structural alterations. Maintaining these parameters within optimal ranges could help mitigate the risk of vision impairment.</p>
19 Keywords
- Aged
- Biological Specimen Banks
- Blood Glucose
- Body Mass Index
- Cataract
- Diabetic Retinopathy
- Female
- Follow-Up Studies
- Humans
- Incidence
- Male
- Middle Aged
- Obesity
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Triglycerides
- UK Biobank
- United Kingdom
7 Authors
- Zhiqian Huang
- Linge Jian
- Jing Xiang
- Yu Du
- Shuyu Liu
- Yi Lu
- Xiangjia Zhu
1 Application
| Application ID | Title |
|---|---|
| 93118 | Associations of lifestyle risk factors, ocular diseases, and mental disorders. |
Enabling scientific discoveries that improve human health