| Title: | Integrated plasma proteomics and metabolomes reveal potential biomolecules linking PM2.5 to depression |
| Journal: | Environmental Toxicology and Pharmacology |
| Published: | 20 Aug 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42624341/ |
| DOI: | https://doi.org/10.1016/j.etap.2026.105144 |
Publication 20949
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Abstract
The biomolecular pathways linking fine particulate matter (PM2.5) and its constituents to depression remain elusive. With 24,940 depression-free participants in the UK Biobank, exposure to PM2.5 and its 5 constituents (ammonium, nitrate, sulfate, elemental carbon, and organic carbon) was estimated. We integrated Olink-based proteomics and NMR-based metabolomics using Cox proportional hazards models, mediation analyses, functional enrichment analyses, and drug predictive analyses. We identified 982 depression cases during a mean follow-up of thirteen years. PM2.5 and its constituents was associated with increased depression risk, with HRs up to 1.20 per SD increment in ammonium. We identified 140 proteins and 3 metabolites as statistically-significant mediators, with mediation proportions up to 8.00% and 3.42%. These mediators were enriched in lipid and unsaturated fatty acid metabolism, immune regulation, and inflammation responses. Drug predictive analyses showed potential drug repurposing. Shifts in biomolecules partially explained PM2.5-depression associations, highlighting inflammation and lipid dysregulation as potential pathways.</p>
7 Authors
- Lan Chen
- Dashan Zheng
- Shengtao Wei
- Ge Chen
- Yang Shen
- Leiyuan Liu
- Hualiang Lin
1 Application
| Application ID | Title |
|---|---|
| 69550 | Identifying the potential effects of environmental and other healthcare related factors influencing health outcomes, mediated by genetic variances |
Enabling scientific discoveries that improve human health