| Title: | Association between grip strength and major adverse cardiovascular events in patients with metabolic dysfunction-associated steatotic liver disease: a prospective cohort study in the UK Biobank |
| Journal: | Frontiers in Endocrinology |
| Published: | 25 Aug 2026 |
| DOI: | https://doi.org/10.3389/fendo.2026.1914934 |
| URL: | http://dx.doi.org/10.3389/fendo.2026.1914934 |
Publication 20910
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Abstract
Cardiovascular disease represents the primary cause of mortality among individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). We aimed to examine the association between grip strength and the risk of incident major adverse cardiovascular events (MACE) in this population. This prospective cohort analysis included participants with MASLD from the UK Biobank. Participants were categorized into high, medium, and low grip strength groups based on sex-specific tertiles. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between grip strength and incident MACE and its components (heart failure, myocardial infarction, and stroke). A total of 119, 004 participants with MASLD were included (mean [SD] age, 57.24 [7.89] years; 69, 421 men [58.3%]). During a median (IQR) follow-up of 13.6 (12.7-14.4) years, 14, 137 (11.9%) incident MACE cases were recorded. Compared with the high grip strength group, the low grip strength group exhibited a higher risk of MACE (HR = 1.35, 95% CI: 1.29-1.41, P < 0.001), heart failure (HR = 1.52, 95% CI: 1.42-1.62, P < 0.001), myocardial infarction (HR = 1.26, 95% CI: 1.19-1.34, P < 0.001), and stroke (HR = 1.33, 95% CI: 1.21-1.45, P < 0.001). A significant interaction between grip strength and sex was observed (P for interaction = 0.001), with the association between low grip strength and MACE being stronger in women (HR = 1.45, 95% CI: 1.34-1.56, P < 0.001) than in men (HR = 1.29, 95% CI: 1.16-1.45, P < 0.001). No significant interaction was observed for age. In individuals with MASLD, lower grip strength was associated with an increased risk of MACE, with a stronger association observed in women. These findings highlight grip strength as a potential marker of cardiovascular risk among individuals with MASLD.</p>
4 Authors
- Yanxiao Xie
- Ren Lin
- Ziqi Zhang
- LeShen Lian
1 Application
| Application ID | Title |
|---|---|
| 221713 | Exploring the associations of lifestyle, environmental and genetic factors on metabolic diseases and cancer |
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