| Title: | Pregnancy loss, healthy lifestyle behaviours, and long-term risk of hospital-treated infections: a prospective cohort study |
| Journal: | Reproductive Health |
| Published: | 25 Aug 2026 |
| DOI: | https://doi.org/10.1186/s12978-026-02438-2 |
| URL: | http://dx.doi.org/10.1186/s12978-026-02438-2 |
Publication 20895
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Abstract
BackgroundPregnancy loss (PL) is a common reproductive event that may reflect underlying biological vulnerability with potential implications for women's long-term health. We aimed to investigate the associations of PL and healthy lifestyle with hospital-treated infections and to quantify their combined effects.MethodsUsing data from 179,971 women in the UK Biobank, Cox proportional hazards regression models were applied to examine the association between the joint effects of PL and the healthy lifestyle index (HLI) and the risk of hospital-treated infections.ResultsWomen with a history of PL had a higher risk of hospital-treated infections in a dose-dependent manner. Specifically, women who experienced two or more PLs had a 23% higher risk of hospital-treated infections (adjusted HR = 1.23, 95% CI: 1.18-1.28), whereas those with a high HLI level had a 31% lower risk (adjusted HR = 0.69, 95% CI: 0.68-0.71). In the joint analysis, compared with women with two or more PLs and a low HLI level, those with no history of PL and a high HLI level had the lowest risk of hospital-treated infections (adjusted HR = 0.56, 95% CI: 0.52-0.60), particularly among participants with low income. No significant additive interaction between PL and HLI was observed after Holm correction; the largest positive departure from additivity was found among women with two or more PLs and a low HLI level (RERI = 0.15, 95% CI: − 0.01 to 0.30; Holm-adjusted P = 0.247).ConclusionPL was associated with a higher long-term risk of hospital-treated infections, while adherence to a healthy lifestyle was associated with a substantially lower risk and partially attenuated the excess infection risk associated with PL, highlighting the potential importance of lifestyle modification for long-term infection risk among women with a history of PL.</p>
8 Authors
- Hao Liu
- Yan Chen
- Han Qu
- Zhaochen Sun
- Juan Jiang
- Yiheng Yin
- Yuping Liu
- Zhengwei Wan
1 Application
| Application ID | Title |
|---|---|
| 158316 | Investigating associations between infections and cancers, CVD and neurodegenerative diseases, and developing risk prediction and prognostic models for the aforementioned common diseases |
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