| Title: | Associations of social isolation and loneliness with neurological disorders, psychiatric disorders, brain structures and behavioural phenotypes among UK Biobank participants |
| Journal: | Nature Communications |
| Published: | 28 Apr 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42049746/ |
| DOI: | https://doi.org/10.1038/s41467-026-72529-y |
Publication 17815
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Abstract
Social isolation and loneliness are increasingly recognized as detrimental risk factors for brain health. Here, utilizing data from 383,421 participants in the UK Biobank, we identify significant associations between social isolation, loneliness, and the incidence of 11 neurological and psychiatric disorders, including major depressive disorder (MDD), schizophrenia, bipolar disorder, anxiety disorders, sleep disorders, dementia, Alzheimer's disease, Parkinson's disease, stroke, multiple sclerosis, and epilepsy employing Cox regression models. Furthermore, using Mendelian randomization analysis we find evidence for putative relationships from social isolation and loneliness to MDD, schizophrenia, sleep disorders, and epilepsy. We also observe significant associations between social isolation, loneliness, and worse cognitive and emotional performance, as well as alterations in brain structures. Additionally, mediation analyses indicate that peripheral inflammatory and biochemical markers partially mediated the links from social isolation and loneliness to neurological and psychiatric disorders.</p>
13 Authors
- Yong-Li Zhao
- Dan-Dan Zhang
- Pei-Yang Gao
- Yan Fu
- Yi-Jun Ge
- Hao-Chen Chi
- Ze-Xin Guo
- Hai-Hong Yu
- Jian-Feng Feng
- Lan Tan
- Wei Cheng
- Ya-Ru Zhang
- Jin-Tai Yu
1 Application
| Application ID | Title |
|---|---|
| 19542 | Identifying multi-level biomarkers and disease mechanisms for major mental disorders |
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