| Title: | High-Density Lipoprotein Cholesterol Links Peripheral Lipid Metabolism to Brain Structure and Cognition |
| Journal: | Acta Neurologica Scandinavica |
| Published: | 1 Jan 2025 |
| DOI: | https://doi.org/10.1155/ane/8831825 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/ane/8831825 |
Publication 16831
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Abstract
Objective The objective of this study is to assess dementia risk and cognitive function in relation to serum lipid levels and to elucidate the potential neurobiological mechanisms underlying these associations, which may be mediated by alterations in brain structures. Methods This study utilized UK Biobank data, incorporating dementia diagnoses, biochemistry tests, and brain structural imaging. The associations between baseline serum lipid levels and dementia diagnosis during follow-up were analyzed using generalized additive models with shrinkage smoothers. The associations between serum lipid levels and brain structure measures were also explored. Structural equation modeling was employed to elucidate the potential links between serum lipids, brain structures, and cognitive impairment. Results In 283,234 participants, combining dementia diagnoses with blood biochemistry data, HDL-C levels showed a nearly significant negative linear correlation with dementia diagnosis (edf ≈ 1, p = 0.057) after appropriate adjustments. HDL-C also exhibited linear associations with several brain structure indicators, including the volume of the right accumbens area and the central corpus callosum, the area of the superior parietal region, and the mean cortical thickness of the right lateral occipital, right superior frontal, and left transverse temporal regions. Structural equation modeling in 19,707 participants revealed that HDL-C was a significant negative predictor of cognitive impairment, with this association potentially mediated by the positive effect of HDL-C on brain volume. Conclusion These findings suggest a potential protective role of HDL-C against dementia and highlight dietary interventions as a feasible and accessible strategy for dementia prevention. </p>
10 Authors
- Jiatong Li
- Tianshu Guan
- Dongqing Zhu
- Wenbo Yang
- Liu Yang
- Weikang Gong
- Xiaoni Liu
- Jia You
- Jianfeng Feng
- Xiangjun Chen
Enabling scientific discoveries that improve human health