| Title: | Blood pressure levels and risk of intracerebral hemorrhage in the general population: evidence from a large prospective cohort study |
| Journal: | Journal of Stroke and Cerebrovascular Diseases |
| Published: | 18 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41115488/ |
| DOI: | https://doi.org/10.1016/j.jstrokecerebrovasdis.2025.108476 |
| URL: | https://www.strokejournal.org/article/S1052-3057(25)00253-8/pdf |
Publication 16705
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Abstract
BACKGROUND AND OBJECTIVES: Although elevated blood pressure (BP) is a known risk factor for intracerebral hemorrhage (ICH), the optimal BP range associated with lower ICH risk in the general population remains uncertain.This study aimed to explore the association between baseline systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels and the risk of incident ICH, using stage 1 hypertension (SBP 130-139 mmHg or DBP 80-89 mmHg) as the reference.</p>
METHODS: This prospective cohort study included 351,369 participants from the UK Biobank without prior stroke and coronary heart disease at baseline. Participants were categorized by BP levels, and Cox proportional hazards models were used to evaluate the associations between SBP and DBP categories and incident ICH, adjusting for demographic and clinical covariates.</p>
RESULTS: During a median follow-up of 12.77 years, 1,126 cases of incident ICH were identified. Compared to SBP 130-139 mmHg, SBP 110-119 mmHg was associated with a significantly lower risk of ICH (HR: 0.67, 95 % CI: 0.50-0.88). Similarly, DBP 70-79 mmHg was associated with a lower risk (HR: 0.86, 95 % CI: 0.74-1.00) compared to DBP 80-89 mmHg. However, further reductions below these levels were not associated with additional statistically significant risk reduction.</p>
CONCLUSION: In this large cohort of adults without baseline stroke and coronary heart disease, moderately lower BP levels were associated with reduced risk of incident ICH. These findings may help refine our understanding of BP thresholds relevant to ICH risk in primary prevention settings.</p>
11 Authors
- Han Wang
- Gao-Cai Zhang
- Shu-Yang Dong
- Zi-Jie Wang
- Zhi-Ming Li
- Yi Qian
- Xiao Hu
- Shan-Yu Zhang
- Chu Chen
- Tian-Nan Yang
- Qi Li
1 Application
| Application ID | Title |
|---|---|
| 100889 | Role of vascular and behavioral risk factors, genes and imaging markers in cerebrovascular disease and cognitive impairment |
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