| Title: | Difference between estimated GFR based on cystatin C versus creatinine and incident dementia, cognitive functions and biological aging: A cohort study of the UK Biobank |
| Journal: | Experimental Gerontology |
| Published: | 20 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41115669/ |
| DOI: | https://doi.org/10.1016/j.exger.2025.112933 |
Publication 16701
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Abstract
BACKGROUND: Associations between the differences of estimated glomerular filtration rate (eGFRdiff) based on cystatin C (eGFRcys) and creatinine (eGFRcr) and dementia risk remains unknown. This study aims to examine the associations between eGFRdiff and dementia, including its common subtypes, and to explore whether there is a correlation of eGFRdiff with cognitive functions and biological aging.</p>
METHODS: A cohort consisting of 498,711 dementia-free participants was included based on the UK Biobank. The eGFRdiff calculated as eGFRcys minus eGFRcr was categorized into three groups including negative (<-15 mL/min/1.73 m2), midrange (-15-15 mL/min/1.73 m2) and positive (≥15 mL/min/1.73 m2). Multivariate Cox proportional hazards regression models, logistic regression models and general linear models were applied to explore associations of eGFRdiff with dementia, cognitive functions and biological aging.</p>
RESULTS: During a median follow-up of 13 years, 8171 all-cause dementia [ACD, including 5144 Alzheimer's disease (AD) and 1593 vascular dementia (VD)] events were recorded. In multivariate models adjusting for genetic and biological factors, lifestyle factors and socioeconomic factors, participants with negative eGFRdiff had a 27 % higher risk of ACD (HR = 1.27, 95 % CI: 1.20-1.34), worse cognitive functions and a 24 % ∼ 46 % increase in the risk of biological age acceleration, while there are significant associations of positive eGFRdiff with lower risks of dementia, cognitive decline and biological aging, compared to those with a midrange eGFRdiff.</p>
CONCLUSIONS: A negative eGFRdiff (eGFRcys-eGFRcr < -15 mL/min/1.73m2) was associated with a higher risk of dementia, poorer cognitive functions, and worse biological age acceleration. While those with a positive eGFRdiff had a lower risk.</p>
10 Authors
- Yiqun Li
- Wenyang Han
- Pinni Yang
- Yiming Jia
- Lulu Sun
- Ruirui Wang
- Mengyao Shi
- Xiaowei Zheng
- Yonghong Zhang
- Zhengbao Zhu
Enabling scientific discoveries that improve human health