| Title: | Distinct spatiotemporal patterns of white matter hyperintensity progression |
| Journal: | Nature Communications |
| Published: | 24 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41136463/ |
| DOI: | https://doi.org/10.1038/s41467-025-64704-4 |
| URL: | https://www.nature.com/articles/s41467-025-64704-4.pdf |
Publication 16643
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Abstract
White matter hyperintensity, a key imaging biomarker for brain health, has prognostic implications for stroke. Using a multicenter MRI dataset of 9179 stroke patients plus the UK Biobank (n = 36,210 low/high risk controls), we employ Subtype and Stage Inference modeling and identify three distinct white matter hyperintensity progression subtypes: fronto-parietal, radial, and temporo-occipital. Longitudinal validation confirms classification stability. The fronto-parietal subtype shows delayed onset and more hypertension, while the temporo-occipital subtype has more atrial fibrillation and coronary heart disease. The fronto-parietal and radial subtypes are linked to small vessel stroke, while the temporo-occipital subtype is linked to cardioembolism. The fronto-parietal subtype has higher 1-year ischemic stroke recurrence, while the temporo-occipital subtype shows a higher incidence of early neurological deterioration by symptomatic hemorrhagic transformation and worse 3-month outcomes. Beyond capturing progression, demographics, and vascular risks, and improving post-stroke outcome prediction, this subtyping-staging model also holds potential for stroke prediction.</p>
12 Keywords
- Aged
- Brain
- Disease Progression
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Prognosis
- Risk Factors
- Stroke
- White Matter
35 Authors
- Jinyong Chung
- Gilsoon Park
- Wi-Sun Ryu
- Dawid Schellingerhout
- Hang-Rai Kim
- Dong-Seok Gwak
- Elizabeth Haddad
- Neda Jahanshad
- Beom Joon Kim
- Keun-Sik Hong
- Hyerin Oh
- Sang-Wuk Jeong
- Joon-Tae Kim
- Man Seok Park
- Kang-Ho Choi
- Kyungbok Lee
- Tai Hwan Park
- Sang-Soon Park
- Jong-Moo Park
- Kyusik Kang
- Kyung-Ho Yu
- Mi Sun Oh
- Soo Joo Lee
- Jae Guk Kim
- Jae-Kwan Cha
- Dae-Hyun Kim
- Jun Lee
- Moon-Ku Han
- Yong-Jin Cho
- Byung-Chul Lee
- Philip M. Bath
- Joanna M. Wardlaw
- Hee-Joon Bae
- Hosung Kim
- Dong-Eog Kim
1 Application
| Application ID | Title |
|---|---|
| 11559 | Enhancing Neuro Imaging Genetics through Meta Analysis |
Enabling scientific discoveries that improve human health