| Title: | Sex differences in the association of wearable accelerometer-derived physical activity with coronary heart disease incidence and mortality |
| Journal: | Nature Cardiovascular Research |
| Published: | 27 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41145891/ |
| DOI: | https://doi.org/10.1038/s44161-025-00732-z |
| URL: | https://www.nature.com/articles/s44161-025-00732-z.pdf |
Publication 16633
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Abstract
Despite American Heart Association, European Society of Cardiology and World Health Organization (AHA/ESC/WHO) guidelines uniformly recommending 150 min week−1 of moderate-to-vigorous physical activity (MVPA) for both sexes, a substantial 'gender gap' persists in exercise capacity and guideline adherence, and its impact on coronary heart disease (CHD) development and prognosis remains underexplored. Here we analyzed the accelerometer-measured MVPA of 80,243 CHD-free participants to assess CHD incidence and 5,169 patients with CHD to evaluate all-cause mortality. Compared with non-adherent counterparts, guideline-adherent participants showed a 22% lower CHD risk in female individuals (hereinafter referred to as females) and a 17% lower CHD risk in male individuals (hereinafter referred to as males; (Pinteraction = 0.009). Notably, females achieved a CHD risk reduction of 30% (hazard ratio (HR) = 0.70) with 250 min week−1 of MVPA, whereas males required 530 min week−1 for comparable benefits. Among patients with CHD, active females experienced greater mortality risk reduction than males (HR = 0.30 versus 0.81; Pinteraction = 0.004). Similar sex differences were observed when analyzing guideline-adhering days (Pinteraction < 0.05). Our findings underscore the value of sex-specific tailored CHD prevention strategies using wearable devices, which may help bridge the 'gender gap' by motivating females to engage in physical activity.</p>
18 Keywords
- Accelerometry
- Actigraphy
- Aged
- Coronary Disease
- Exercise
- Female
- Fitness Trackers
- Health Status Disparities
- Healthy Lifestyle
- Humans
- Incidence
- Male
- Middle Aged
- Protective Factors
- Risk Assessment
- Risk Reduction Behavior
- Sex Factors
- Time Factors
8 Authors
- Jiajin Chen
- Yuliang Wang
- Zihang Zhong
- Xin Chen
- Le Zhang
- Lingjun Jie
- Yangyang Zhang
- Yan Wang
1 Application
| Application ID | Title |
|---|---|
| 134551 | Study on relationships between omics traits, environmental exposures, and common chronic diseases |
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