| Title: | Multi-cohort high-dimensional proteomics reveals early risk markers for lymphoid cancer subtypes |
| Journal: | Nature Communications |
| Published: | 28 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41152224/ |
| DOI: | https://doi.org/10.1038/s41467-025-64534-4 |
| URL: | https://www.nature.com/articles/s41467-025-64534-4.pdf |
Publication 16630
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
This study aims to investigate the early stages of lymphoid malignancy pathogenesis and identify pre-diagnostic proteomic markers for lymphoma. Using the SomaScan-7K platform, we analyze 6412 unique plasma proteins in a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, comprising 4565 participants (484 incident lymphoid malignancy cases, median follow-up 9 years). We identify over 500 unique protein-lymphoid malignancy associations. Enriched pathways include viral protein interactions, cytokine signaling, B-cell receptor signaling, and NF-κB activation, reflecting key mechanisms in lymphoma pathogenesis. Cross-cohort validation of the top 20 FDR-significant proteins reveals concordant nominal significance for 70%-95% of the associations in the UK Biobank (Olink) and ARIC (SomaScan) studies. Time-stratified analyses reveals that a subset of these protein-lymphoma associations is evident over a decade before diagnosis. These findings highlight the potential of circulating proteomic markers in risk stratification, early diagnosis, and targeted prevention strategies for lymphoid malignancies.</p>
12 Keywords
- Aged
- Biomarkers, Tumor
- Blood Proteins
- Cohort Studies
- Female
- Humans
- Lymphoma
- Male
- Middle Aged
- Prospective Studies
- Proteomics
- Risk Factors
22 Authors
- P. Martijn Kolijn
- Karl Smith-Byrne
- Vernon Burk
- Vivian Viallon
- Matthew A. Lee
- Keren Papier
- Ziqiao Wang
- Anton W. Langerak
- Florentin Späth
- Arjan Diepstra
- Christina M. Lill
- Raul Zamora-Ros
- Alessandra Macciotta
- Amaia Aizpurua
- Rosario Tumino
- Nilanjan Chatterjee
- Ruth C. Travis
- Marc J. Gunter
- Elizabeth A. Platz
- Elio Riboli
- James McKay
- Roel C. H. Vermeulen
1 Application
| Application ID | Title |
|---|---|
| 67506 | Characterisation of risk factors and their mechanisms in the development of both common and relatively understudied conditions |
Enabling scientific discoveries that improve human health