| Title: | Comprehensive dietary patterns explain acquired cystic kidney disease risk through genetic and metabolomic mechanisms |
| Journal: | Frontiers in Nutrition |
| Published: | 29 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41235303/ |
| DOI: | https://doi.org/10.3389/fnut.2025.1611656 |
| URL: | https://public-pages-files-2025.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1611656/pdf |
Publication 16621
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Abstract
Background: Acquired renal cysts (ARC) are associated with kidney function decline, necessitating novel dietary pattern (DP) analyses in large cohorts.</p>
Methods: This UK Biobank prospective cohort study (2006-2010) included participants with ≥2 dietary records, excluding those with severe kidney damage. The constructed comprehensive dietary pattern integration (CDPI) utilized reduced rank regression (RRR) and latent profile analysis (LPA). ARC cases (ICD-10: N28.1) were assessed via Cox regression for risk and dose-response, with NMR metabolites examined as mediators.</p>
Results: Among 119,709 participants (median follow-up: 10.57 years), 850 ARC cases were identified. Lipid-rich and hyperglycemic diets increased ARC risk [e.g., HRs for G1.DP1: 1.080 (1.024, 1.139); G1.DP2: 1.144 (1.048, 1.249)], while micronutrient-rich diets showed weak protective effects [G4.DP1: 0.943 (0.892, 0.998)]. LPA confirmed RRR findings, and 7/251 NMR metabolites had significant mediating effects.</p>
Conclusion: Diets high in fat (cheese, butter, pizza) and sugar (chocolate, sugary drinks) elevated ARC risk, whereas micronutrient- and fiber-rich diets (vegetables, fruit, lean poultry, nuts, eggs) were protective. Key mediators included branched-chain amino acids, IGF-1, and RBC distribution width.</p>
12 Authors
- Chenhao Xu
- Junjie Zhao
- Kan Wu
- Shengzhuo Liu
- Fan Zhang
- Qin Cao
- Zhouwei Wan
- Yongquan Tang
- Zhihong Liu
- Hao Zeng
- Xianding Wang
- Jiayu Liang
Enabling scientific discoveries that improve human health