| Title: | Diurnal Light Exposure and Rest-Activity Rhythms in Relation to MASLD: Insights From 2 Nationwide Cohort Studies |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 29 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41160717/ |
| DOI: | https://doi.org/10.1210/clinem/dgaf593 |
| URL: | https://academic.oup.com/jcem/advance-article-pdf/doi/10.1210/clinem/dgaf593/65026567/dgaf593.pdf |
Publication 16619
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Abstract
BACKGROUND: Circadian rhythms may influence metabolic dysfunction-associated steatotic liver disease (MASLD), but the impact of personal light exposure and rest-activity rhythms on MASLD risk remain unclear.</p>
METHODS: The study utilized accelerometry data from both NHANES and UK Biobank cohorts. 24-hour rest-activity rhythm (24h-RAR) was assessed using nonparametric metrics, including activity level during the most active 10 hours (M10), activity level during the least active 5 hours (L5), relative amplitude (RA), M10 onset, and L5 onset. Light exposure was categorized into daytime and nighttime periods, with exposure durations recorded separately at different threshold levels. The primary outcome was MASLD, with secondary outcomes, including fibrosis and cirrhosis.</p>
RESULTS: In the UK Biobank prospective analysis, each 0.1-unit and 1-unit increase in RA and M10 were associated with a 30% and 2% reduction of MASLD risk, respectively. In contrast, each 1-unit increase in L5 and delayed L5 onset were linked to an 8% and 21% increase of MASLD risk. Moreover, each additional hour of daylight exposure above 6000 lux was associated with 9% lower risk of MASLD, while each additional 30 minutes of nightlight exposure above 30 lux corresponded to a 22% higher risk of MASLD. Additionally, a favorable 24h-RAR profiles and adequate light exposure were associated with a lower risk of fibrosis and cirrhosis, as well as improved life expectancy among participants with MASLD. Similar associations were observed in the NHANES analysis.</p>
CONCLUSION: Greater daytime light exposure, reduced nocturnal light exposure, and regulated rest-activity rhythms may protect against MASLD and prevent its progression to liver fibrosis and advanced liver disease.</p>
9 Authors
- Hanzhang Wu
- Wei Wang
- Bingtao Weng
- Jiahe Wei
- Ningjian Wang
- Jihui Zhang
- Xiaoyu Li
- Hongliang Feng
- Xiao Tan
1 Application
| Application ID | Title |
|---|---|
| 58082 | Using Mendelian Randomization to investigate the causal associations between rest-activity patterns and common diseases |
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