| Title: | Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias |
| Journal: | Alzheimer's & Dementia |
| Published: | 27 May 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40421744/ |
| DOI: | https://doi.org/10.1002/alz.70215 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.70215 |
Publication 15212
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Abstract
INTRODUCTION: Limited information is available regarding sex differences in the relationship of socioeconomic status and cognitive performance with Alzheimer's disease and related dementias (ADRD) family history.</p>
METHODS: Leveraging the UK Biobank (N = 448,100) and All of Us Research Program (N = 240,319), we conducted observational and genetically informed analyses to test the sex-specific associations of socioeconomic factors and cognitive performance with ADRD and its family history.</p>
RESULTS: Observational and genetically informed analyses highlighted that higher socioeconomic status and cognitive performance were associated with reduced ADRD and sibling-ADRD family history. Conversely, these were associated with increased parent-ADRD family history. Sex differences in these relationships were also identified. Additionally, although their sample size was limited, population minorities showed different patterns with respect to ADRD versus parent-ADRD family history.</p>
DISCUSSION: This study highlights sex differences in the misestimated associations of ADRD family history that appear to be related to socioeconomic factors and cognitive performance.</p>
HIGHLIGHTS: Alzheimer's disease family history is differently linked to socioeconomic factors. Observational and genetic analyses highlighted sex differences in these dynamics. Cause-effect relationships could contribute to biases in Alzheimer's disease assessment.</p>
13 Keywords
- Aged
- Alzheimer Disease
- Cognition
- Dementia
- Female
- Humans
- Male
- Middle Aged
- Sex Characteristics
- Sex Factors
- Social Class
- Socioeconomic Factors
- United Kingdom
7 Authors
- Jun He
- Brenda Cabrera-Mendoza
- Eleni Friligkou
- Adam P. Mecca
- Christopher H. van Dyck
- Gita A. Pathak
- Renato Polimanti
1 Application
| Application ID | Title |
|---|---|
| 58146 | The causes and consequences of pleiotropy across the human phenome |
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