| Title: | Joint Associations of Sedentary Time and Intensity-Specific Physical Activity With Cancer Mortality: A Device-Based Cohort Study of 72,458 UK Adults. |
| Journal: | Journal of Physical Activity and Health |
| Published: | 25 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39798552/ |
| DOI: | https://doi.org/10.1123/jpah.2024-0436 |
Publication 14940
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Abstract
BACKGROUND: There are no studies examining the prospective joint association of device-based measures of sedentary time and physical activity (PA) with cancer mortality. We examined the joint associations of sedentary time and intensity-specific PA with cancer mortality in 72,458 adults from UK Biobank.</p>
METHODS: Participants wore an Axivity AX3 accelerometer on their dominant wrist for at least 3 days (with at least 1 weekend day). Cox regression was performed to estimate hazard ratios (HR) and 95% confidence intervals (CIs) for joint associations of sedentary time and intensity-specific PA (light [LPA], moderate [MPA], and vigorous PA [VPA]) with cancer mortality (reference group: high intensity-specific PA and low sedentary time) adjusted for confounders and mutually adjusted for other PA intensities.</p>
RESULTS: Associations between sedentary time and cancer mortality were stronger among participants with low PA, irrespective of the intensity. Compared with participants with lower sedentary time (<11 h/d) and high MPA (median of 49 min/d), HR were 1.27 (95% CI, 0.90-1.78) for high sedentary time and high MPA, 1.35 (95% CI, 1.03-1.77) for high sedentary time and medium MPA (49 min/d), and 1.49 (95% CI, 1.15-1.92) for high sedentary time and low MPA (13 min/d). HR for high sedentary time and low light PA (61 min/d) and high sedentary time and low vigorous PA (1 min/d) were 1.25 (95% CI, 1.02-1.59) and 1.57 (95% CI, 1.20-2.06), respectively.</p>
CONCLUSIONS: Relatively large amounts of LPA and MPA and small amounts of VPA appeared to attenuate the association between sedentary time and cancer mortality.</p>
14 Keywords
- Accelerometry
- Adult
- Aged
- Exercise
- Female
- Humans
- Male
- Middle Aged
- Neoplasms
- Proportional Hazards Models
- Prospective Studies
- Sedentary Behavior
- Time Factors
- United Kingdom
7 Authors
- Leandro F M Rezende
- Matthew Ahmadi
- Gerson Ferrari
- Borja Del Pozo Cruz
- I-Min Lee
- Christine M Friedenreich
- Emmanuel Stamatakis
1 Application
| Application ID | Title |
|---|---|
| 25813 | Integrated paradigms to investigate the interplay between lifestyle behaviours, the social environment, and genetic risk in the development of cardio- metabolic disease and mental health. |
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