| Title: | Association between fat mass and mortality: analysis of Mendelian randomization and lifestyle modification |
| Journal: | Metabolism |
| Published: | 2 Sep 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36058288/ |
| DOI: | https://doi.org/10.1016/j.metabol.2022.155307 |
Publication 14142
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Abstract
BACKGROUND: The association between fat mass and mortality has been equivocally shown to be linear, J-shaped, and U-shaped. We aimed to clarify this relationship based on Mendelian randomization (MR) analysis and lifestyle modification.</p>
METHODS: This prospective analysis included 449,831 participants from UK Biobank. Linear MR analysis was used to estimate the linear relationship between fat mass and mortality. We assessed whole body fat mass by bioimpedance analysis at baseline and categorized subjects into five equal groups based on fat mass index (FMI). The association between FMI and mortality were investigated among whole population and in subgroups stratified by individual lifestyle factors, including diet, physical activity, smoking, alcohol, sleep and psychological health.</p>
FINDINGS: Linear MR analyses indicated a positive association between genetically predicted fat mass and all-cause mortality (HR 1.10, 95 % CI 1.08-1.12, P < 0.001). The association between FMI and all-cause mortality was manifested as J-shaped (HRs across FMI categories: 1.04, 1.00, 1.07, 1.21, 1.54), which was significantly modified by the number of low-risk lifestyle factors (P for interaction<0.001). When evaluating individual lifestyle factors, we observed a nonlinear relationship between FMI and all-cause mortality among participants who had high-risk lifestyle factors, while a linear relationship was observed among participants who had low-risk lifestyle factors, especially for those with adequate physical activity (HRs across FMI categories: 0.95, 1.00, 1.05, 1.17, 1.44) and who never smoked (0.96, 1.00, 1.03, 1.14, 1.51).</p>
INTERPRETATION: Genetically determined fat mass is causally and linearly associated with mortality. The J-shape association between anthropometric FMI and mortality is caused by high-risk lifestyle factors.</p>
6 Keywords
- Anthropometry
- Body Mass Index
- Diet
- Humans
- Life Style
- Mendelian Randomization Analysis
11 Authors
- Jinbo Hu
- Xiangjun Chen
- Jun Yang
- Edward Giovannucci
- Dong Hoon Lee
- Wenjin Luo
- Qingfeng Cheng
- Lilin Gong
- Zhihong Wang
- Qifu Li
- Shumin Yang
1 Application
| Application ID | Title |
|---|---|
| 66536 | Abdominal obesity and Diabetic Kidney Disease: A Mendelian Randomization Study |
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