| Title: | Application of European-specific polygenic risk scores for predicting prostate cancer risk in different ancestry populations |
| Journal: | The Prostate |
| Published: | 22 Aug 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35996327/ |
| DOI: | https://doi.org/10.1002/pros.24431 |
Publication 14132
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Polygenic risk score (PRS) has shown promise in predicting prostate cancer (PCa) risk. However, the application of PRS in non-European ancestry was poorly studied.</p>
METHODS: We constructed PRS using 68, 86, or 128 PCa-associated single-nucleotide polymorphisms (SNPs) identified through a large-scale Genome-wide association study (GWAS) in the European ancestry population. A calibration approach was performed to adjust the PRS exact value for each ancestry. The study was conducted in East Asian (ChinaPCa Consortium, n = 2379), European (UK Biobank, n = 209,172), and African American (African Ancestry Prostate Cancer Consortium, n = 6016).</p>
RESULTS: Individuals with the highest PRS (in >97.5th percentile) had over 2.5-fold increased risk of PCa than those with average PRS (in 40th-60th percentile) in both European (odds ratio [OR] = 3.79, 95% confidence interval [CI] = 3.46-4.16, p < 0.001) and Chinese (OR = 2.87, 95% CI = 1.29-6.40, p = 0.010), while slightly lower in African American (OR = 1.77, 95% CI = 1.22-2.58, p = 0.008). Compared with the lowest PRS (in <2.5th percentile), increased PRS was also associated with the earlier onset of PCa (All log-rank p < 0.05). The highest PRS contributed to having about 5- to 12-fold higher lifetime risk and 5-10 years earlier at disease onset than the lowest category across different ancestry populations.</p>
CONCLUSION: We demonstrated that European-GWAS-based PRS could also significantly predict PCa risk in Asian ancestry and African ancestry populations.</p>
7 Keywords
- Black or African American
- East Asian People
- European People
- Genome-Wide Association Study
- Humans
- Prostatic Neoplasms
- Risk Factors
5 Authors
- Xiaohao Ruan
- Da Huang
- Jingyi Huang
- Danfeng Xu
- Rong Na
1 Application
| Application ID | Title |
|---|---|
| 66813 | Comprehensive evaluation of causal relationship among different phenotypes and disease traits by Mendelian Randomization using Genetic Instruments |
Enabling scientific discoveries that improve human health