| Title: | Vitamin D status and asthma, lung function, and hospitalization among British adults |
| Journal: | Frontiers in Nutrition |
| Published: | 10 Aug 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36034921/ |
| DOI: | https://doi.org/10.3389/fnut.2022.954768 |
| URL: | https://www.frontiersin.org/articles/10.3389/fnut.2022.954768/pdf |
Publication 14126
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Abstract
Background: Vitamin D has been known to be associated with asthma. However, the association between vitamin D status and asthma, lung function as well as hospitalization among adults remains unclear.</p>
Objective: To investigate the role of serum vitamin D in asthma prevalence, lung function, and asthma control in adults.</p>
Methods: Multivariable logistic regression was applied to assess the relationship between serum vitamin D and asthma prevalence, lung function (FEV1, FVC, and FEV1/FVC), current wheeze, and asthma-linked hospitalizations in a cross-sectional study of 435,040 adults aged 37-73 years old from the UK Biobank.</p>
Results: Compared to vitamin D deficiency, the odds of asthma were decreased by 6.4% [adjusted odds ratio (aOR) = 0.936; 95% CI: 0.911-0.962; p < 0.001] and 9.8% (aOR = 0. 0.902; 95% CI: 0.877-0. 0.927; p < 0.001) in individuals with insufficient and optimal vitamin D concentration, respectively, in the fully adjusted model. In total asthmatic patients, serum vitamin D was obviously and positively related with FEV1 (β = 1.328 ml, 95% CI = 0.575-2.080), FVC (β = 2.018 ml, 95% CI = 1.127-2.908), and FEV1/FVC (β = 0.006%, 95% CI = 0.002-0.010). Asthmatic patients whose vitamin D level was in the deficient category had 9.3-19.9% higher odds of current wheeze than insufficient categories (aOR = 0.907; 95% CI: 0.861-0.957; p < 0.001) and optimal categories (aOR = 0.801; 95% CI: 0.759-0.845; p < 0.001), but the relationship between vitamin D and asthma hospitalization was not significant.</p>
Conclusion: Vitamin D deficiency was related to higher odds of asthma and current wheeze, and lower lung function in a large sample size study of British adults. Our results indicate a potential positive impact of serum vitamin D on asthma occurrence and disease control in adults.</p>
9 Authors
- Yiqun Zhu
- Danrong Jing
- Huaying Liang
- Dianwu Li
- Qinyu Chang
- Minxue Shen
- Pinhua Pan
- Hong Liu
- Yan Zhang
1 Application
| Application ID | Title |
|---|---|
| 84979 | Associations of Lifestyle and Genetic Risk with Incidence of Respiratory Diseases |
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