| Title: | Sugar-sweetened beverages, artificially sweetened beverages and natural juices and risk of inflammatory bowel disease: a cohort study of 121,490 participants |
| Journal: | Alimentary Pharmacology & Therapeutics |
| Published: | 18 Jul 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35848057/ |
| DOI: | https://doi.org/10.1111/apt.17149 |
| URL: | https://discovery.ucl.ac.uk/10153080/1/Aliment%20Pharmacol%20Ther%20-%202022%20-%20Fu.pdf |
Publication 14114
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Abstract
BACKGROUND: Inflammatory bowel diseases (IBD) have been related to high-sugar dietary patterns, but the associations of different types of beverages with IBD risk are largely unknown.</p>
AIMS: To examine any associations between intake of sugar-sweetened beverages, artificially sweetened beverages and natural juices and IBD risk METHODS: This cohort study included 121,490 participants in the UK Biobank who were free of IBD at recruitment. Intake of beverages was obtained from repeated 24-h diet recalls in 2009-2012. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of beverage intake with IBD risk.</p>
RESULTS: During a mean (standard deviation) follow-up of 10.2 (1.5) years, we documented 510 incident IBD cases, (143 Crohn's disease (CD) and 367 ulcerative colitis (UC)). Compared to non-consumers, participants consuming >1 unit per day of sugar-sweetened beverages were at significantly higher risk of IBD (HR 1.51, 95% CI 1.11-2.05), but the trend was non-significant (p-trend = 0.170). This association was significant for CD (HR 2.05, 95% CI 1.22-3.46), but not for UC (HR 1.31, 95% CI 0.89-1.92). We did not observe significant associations for the consumption of artificially sweetened beverages or natural juices.</p>
CONCLUSIONS: Our findings suggest an association between consumption of sugar-sweetened beverages, rather than artificially sweetened beverages or natural juices, and IBD risk.</p>
10 Keywords
- Artificially Sweetened Beverages
- Beverages
- Cohort Studies
- Colitis, Ulcerative
- Crohn Disease
- Humans
- Prospective Studies
- Sugar-Sweetened Beverages
- Sugars
- Sweetening Agents
9 Authors
- Tian Fu
- Hui Chen
- Xuejie Chen
- Yuhao Sun
- Ying Xie
- Minzi Deng
- Therese Hesketh
- Xiaoyan Wang
- Jie Chen
1 Application
| Application ID | Title |
|---|---|
| 73595 | Comorbidities and Systemic Inflammation Related Outcomes of Inflammatory Bowel Disease |
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