| Title: | Association between the visceral adiposity index and risks of all-cause and cause-specific mortalities in a large cohort: Findings from the UK biobank |
| Journal: | Nutrition Metabolism and Cardiovascular Diseases |
| Published: | 30 May 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35843793/ |
| DOI: | https://doi.org/10.1016/j.numecd.2022.05.020 |
Publication 13935
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Abstract
BACKGROUND AND AIMS: The visceral adiposity index (VAI) has been recently established as a measure of visceral fat distribution and is shown to be associated with a wide range of adverse health events. However, the precise associations between the VAI score and all-cause and cause-specific mortalities in the general population remain undetermined.</p>
METHODS AND RESULTS: In this large-scale prospective epidemiological study, 357,457 participants (aged 38-73 years) were selected from the UK Biobank. We used Cox competing risk regression models to estimate the association between the VAI score and all-cause, cardiovascular disease (CVD), cancer, and other mortalities. The VAI score was significantly correlated with an increased risk of all-cause mortality (hazard ratio [HR], 1.200; 95% confidence interval [CI], 1.148-1.255; P < 0.0001), cancer mortality (HR, 1.224; 95% CI, 1.150-1.303; P < 0.0001), CVD mortality (HR, 1.459; 95% CI, 1.148-1.255; P < 0.0001), and other mortalities (HR, 1.200; 95% CI, 1.148-1.255; P < 0.0001) after adjusting for a series of confounders. In addition, the subgroup analyses showed that HRs were significantly higher in participants who were male, aged below 65 years, and body mass index less than 25.</p>
CONCLUSION: In summary, VAI was positively associated with an increased risk of all-cause and cause-specific mortalities in a nationwide, well-characterised population identified in a UK Biobank. The VAI score might be a complementary traditional predictive indicator for evaluating the risk of adverse health events in the population of Western adults aged 38 years and older.</p>
13 Keywords
- Adiposity
- Adult
- Biological Specimen Banks
- Body Mass Index
- Cardiovascular Diseases
- Female
- Humans
- Intra-Abdominal Fat
- Male
- Obesity, Abdominal
- Prospective Studies
- Risk Factors
- United Kingdom
11 Authors
- Qida He
- Siyuan Liu
- Zhaolong Feng
- Tongxing Li
- Jiadong Chu
- Wei Hu
- Xuanli Chen
- Qiang Han
- Na Sun
- Hongpeng Sun
- Yueping Shen
1 Application
| Application ID | Title |
|---|---|
| 68136 | Prediction of the risk of morbidity, recurrence and mortality of cardiovascular diseases and cancer: the effect of environmental, clinical and genetic factors |
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