| Title: | Cardiorespiratory fitness, genetic susceptibility, inflammation and risk of incident type 2 diabetes: A population-based longitudinal study |
| Journal: | Metabolism |
| Published: | 16 May 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35588860/ |
| DOI: | https://doi.org/10.1016/j.metabol.2022.155215 |
Publication 13927
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Abstract
OBJECTIVE: To examine whether the association between cardiorespiratory fitness (CRF) and type 2 diabetes (T2D) is modified by genetic susceptibility and inflammation.</p>
PARTICIPANTS: The prospective study included 57,185 participants (40-70 years) who were free from T2D and received the CRF assessment at enrollment (2006-2010) in the UK biobank. CRF was examined through a submaximal cycle ergometer test and expressed in metabolic equivalent of tasks (METs), genetic susceptibility was quantified using a genetic risk score, and inflammation was assessed according to the concentration of C-reactive protein. All these three factors were categorized into tertiles.</p>
RESULTS: During a median follow-up of 10.4 years, 5477 (7.0%) cases of T2D were ascertained. CRF was inversely associated with the risk of T2D in a dose-response manner. The hazard ratio (HR) was 0.85 (95% confidence interval [CI]: 0.79-0.92) per 1 MET increment of CRF. There was a significant interaction between CRF and genetic susceptibility to T2D in relation to the risk of T2D (P for interaction = 0.03). Compared with participants with high CRF and low genetic susceptibility, the HR was 4.98 (95% CI: 3.17-7.82) for those with low CRF and high genetic susceptibility. A similar pattern was observed in participants with low CRF and high inflammation compared with those who had high CRF and low inflammation (HR = 2.53; 95% CI: 1.83-3.48), though the interaction between CRF and inflammation did not reach statistical significance. T2D risk declined progressively with increased CRF among different inflammation categories.</p>
CONCLUSION: Our study reveals that genetic susceptibility may modify the association between CRF and T2D, highlighting that risk of T2D associated with genetics could benefit most from interventions on improving CRF.</p>
10 Keywords
- Cardiorespiratory Fitness
- Diabetes Mellitus, Type 2
- Exercise Test
- Genetic Predisposition to Disease
- Humans
- Inflammation
- Longitudinal Studies
- Physical Fitness
- Prospective Studies
- Risk Factors
4 Authors
- Chenjie Xu
- Yabing Hou
- Keyi Si
- Zhi Cao
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