| Title: | Types of diet, obesity, and incident type 2 diabetes: Findings from the UK Biobank prospective cohort study |
| Journal: | Diabetes Obesity and Metabolism |
| Published: | 25 Apr 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35373896/ |
| DOI: | https://doi.org/10.1111/dom.14711 |
Publication 13910
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Abstract
AIM: To investigate the associations between types of diet and incident type 2 diabetes and whether adiposity mediated these associations.</p>
MATERIALS AND METHODS: In total, 203 790 participants from UK Biobank (mean age 55.2 years; 55.8% women) without diabetes at baseline were included in this prospective study. Using the dietary intake data self-reported at baseline, participants were categorized as vegetarians (n = 3237), fish eaters (n = 4405), fish and poultry eaters (n = 2217), meat eaters (n = 178 004) and varied diet (n = 15 927). The association between type of diet and incident type 2 diabetes was investigated using Cox-proportional hazards models with a 2-year landmark analysis. The mediation role of adiposity was tested under a counterfactual framework.</p>
RESULTS: After excluding the first 2 years of follow-up, the median follow-up was 5.4 (IQR: 4.8-6.3) years, during which 5067 (2.5%) participants were diagnosed with type 2 diabetes. After adjusting for lifestyle factors, fish eaters (HR 0.52 [95% CI: 0.39-0.69]) and fish and poultry eaters (HR 0.62 [95% CI: 0.45-0.88]) had a lower risk of incident type 2 diabetes compared with meat eaters. The association for vegetarians was not significant. Varied diet had a higher risk of type 2 diabetes. Obesity partially mediated the association of fish (30.6%), fish and poultry (49.8%) and varied (55.2%) diets.</p>
CONCLUSIONS: Fish eaters, as well as fish and poultry eaters, were at a lower risk of incident type 2 diabetes than meat eaters, partially attributable to lower obesity risk.</p>
11 Keywords
- Animals
- Biological Specimen Banks
- Diabetes Mellitus, Type 2
- Diet
- Diet, Vegetarian
- Female
- Humans
- Male
- Obesity
- Prospective Studies
- United Kingdom
7 Authors
- Jirapitcha Boonpor
- Fanny Petermann-Rocha
- Solange Parra-Soto
- Jill P. Pell
- Stuart R. Gray
- Carlos Celis-Morales
- Frederick K. Ho
1 Application
| Application ID | Title |
|---|---|
| 7155 | Epidemiology of mental health, cognitive function, pain and cardiometabolic disease. |
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