| Title: | Birth Weight and the Risk of Cardiovascular Outcomes: A Report From the Large Population-Based UK Biobank Cohort Study |
| Journal: | Frontiers in Cardiovascular Medicine |
| Published: | 24 Mar 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35402571/ |
| DOI: | https://doi.org/10.3389/fcvm.2022.827491 |
| URL: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.827491/pdf |
Publication 13892
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Abstract
Background: Birth weight has been reported to be associated with the risk of incident cardiovascular disease (CVD); however, the relationship remains inconclusive. Here, we aimed to prospectively assess the associations between birth weight and CVD risk using the data from UK Biobank, a large-scale, prospective cohort study.</p>
Methods: We included 270,297 participants who were free of CVD at baseline and reported their birth weight for analyses. The primary outcome was incident CVD. Hazard ratios (HRs) and 95% confidence intervals (CIs) for outcomes were calculated using Cox proportional hazards models adjusted for potential confounding variables.</p>
Results: During a median follow-up of 8.07 years (IQR: 7.4-8.7 years), 10,719 incident CVD events were recorded. The HRs for low birth weight vs. normal birth weight (2.5-4.0 kg) were 1.23 (95% CI: 1.09-1.38) for risk of incident CVD, 1.52 (95% CI: 1.18-1.95) for stroke, 1.33 (95% CI: 1.07-1.64) for myocardial infarction, and 1.15 (95% CI: 1.01-1.32) for CHD. For the ones with low birth weight, the risk of CVD is reduced by 11% for every kilogram of birth weight gain. The association of low birth weight with CVD was stronger among those younger than 55 years (p = 0.001). No association between high birth weight and risk of cardiovascular outcomes was found.</p>
Conclusion: Low birth weight was associated with an increased risk of cardiovascular events. These findings highlight the longstanding consequence of low birth weight on cardiovascular system.</p>
9 Authors
- Xin Huang
- Jun Liu
- Lu Qi
- Jonathan D. Adachi
- Jing Wu
- Ziyi Li
- Qiong Meng
- Guowei Li
- Gregory Y. H. Lip
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