| Title: | The Causal Relationships Between Extrinsic Exposures and Risk of Prostate Cancer: A Phenome-Wide Mendelian Randomization Study |
| Journal: | Frontiers in Oncology |
| Published: | 14 Feb 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35237523/ |
| DOI: | https://doi.org/10.3389/fonc.2022.829248 |
| URL: | https://www.frontiersin.org/articles/10.3389/fonc.2022.829248/pdf |
Publication 13868
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Abstract
BACKGROUND: Prostate cancer is the second most common cancer in males worldwide, and multitudes of factors have been reported to be associated with prostate cancer risk.</p>
OBJECTIVES: We aim to conduct the phenome-wide exposed-omics analysis of the risk factors for prostate cancer and verify the causal associations between them.</p>
METHODS: We comprehensively searched published systematic reviews and meta-analyses of cohort studies and conducted another systematic review and meta-analysis of the Mendelian randomization studies investigating the associations between extrinsic exposures and prostate cancer, thus to find all of the potential risk factors for prostate cancer. Then, we launched a phenome-wide two-sample Mendelian randomization analysis to validate the potentially causal relationships using the PRACTICAL consortium and UK Biobank.</p>
RESULTS: We found a total of 55 extrinsic exposures for prostate cancer risk. The causal effect of 30 potential extrinsic exposures on prostate cancer were assessed, and the results showed docosahexaenoic acid (DHA) [odds ratio (OR)=0.806, 95% confidence interval (CI): 0.661-0.984, p=0.034], insulin-like growth factor binding protein 3 (IGFBP-3) (OR=1.0002, 95%CI: 1.00004-1.0004, p=0.016), systemic lupus erythematosus (SLE) (OR=0.9993, 95%CI: 0.9986-0.99997, p=0.039), and body mass index (BMI) (OR=0.995, 95%CI: 0.990-0.9999, p=0.046) were associated with prostate cancer risk. However, no association was found between the other 26 factors and prostate cancer risk.</p>
CONCLUSIONS: Our study discovered the phenome-wide exposed-omics risk factors profile of prostate cancer, and verified that the IGFBP-3, DHA, BMI, and SLE were causally related to prostate cancer risk. The results may provide new insight into the study of the pathogenesis of prostate cancer.</p>
10 Authors
- Dongqing Gu
- Mingshuang Tang
- Yutong Wang
- Huijie Cui
- Min Zhang
- Ye Bai
- Ziqian Zeng
- Yunhua Tan
- Xin Wang
- Ben Zhang
1 Application
| Application ID | Title |
|---|---|
| 45973 | Causal relationships between environmental exposures and risk of human cancers: a phenome-wide mendelian randomization analysis |
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