| Title: | Assessing the joint effects of brain aging and gut microbiota on the risks of psychiatric disorders |
| Journal: | Brain Imaging and Behavior |
| Published: | 25 Jan 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35076893/ |
| DOI: | https://doi.org/10.1007/s11682-022-00630-z |
Publication 13850
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Abstract
Abstract</p>
We aim to explore the potential interaction effects of brain aging and gut microbiota on the risks of sleep, anxiety and depression disorders. The genome-wide association study (GWAS) datasets of brain aging (N = 21,407) and gut microbiota (N = 3,890) were obtained from published studies. Individual level genotype and phenotype data of psychiatric traits (including sleep, anxiety and depression) were all from the UK Biobank (N = 107,947-374,505). We first calculated the polygenic risk scores (PRS) of 62 brain aging modes and 114 gut microbiota taxa as the instrumental variables, and then constructed linear and logistic regression analyses to systematically explore the potential interaction effects of brain aging and gut microbiota on psychiatric disorders. We observed the interaction effects of brain aging and gut microbiota on sleep, anxiety and depression disorders, such as Putamen/caudate T2* vs. Rhodospirillales (β = -0.012, P = 8.4 × 10-4) was negatively associated with chronotype, Fornix MD vs. Holdemanella (β = -0.007, P = 1.76 × 10-2) was negatively related to general anxiety disorder (GAD) scores, and White matter lesions vs. Acidaminococcaceae (β = 0.019, P = 1.29 × 10-3) was positively correlated with self-reported depression. Interestingly, Putamen volume vs. Intestinibacter was associated with all three psychiatric disorders, including chronotype (negative correlation), GAD scores (positive correlation) and self-reported depression (positive correlation). Our study results suggest the significant impacts of brain aging and gut microbiota on the development of sleep, anxiety and depression disorders, providing new clues for clarifying the pathogenesis of these disorders.</p>
7 Keywords
- Aging
- Brain
- Gastrointestinal Microbiome
- Genome-Wide Association Study
- Humans
- Magnetic Resonance Imaging
- Mental Disorders
13 Authors
- Huijie Zhang
- Li Liu
- Shiqiang Cheng
- Yumeng Jia
- Yan Wen
- Xuena Yang
- Peilin Meng
- Chun'e Li
- Chuyu Pan
- Yujing Chen
- Zhen Zhang
- Jingxi Zhang
- Feng Zhang
1 Application
| Application ID | Title |
|---|---|
| 46478 | Multi-omics integrative studies of common psychiatric disorders and skeletal disorders |
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